HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 0.60 0.705

The method score is based on:

Property Details
Experiments 20023648, 25305019, 22508508, 22814251, 26503038
Identification Methods affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006974 - DNA damage response
GO:0008270 - zinc ion binding
and 2 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 485
Hs

1 4834
+ Rn
+ Hs
+ At
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024