HitPredict

Interactor 1: O77430 (O77430)
GEO01111p1 (HL01263p) (RH26825p) (SKP1-related A, isoform A) (SKP1-related A, isoform B) (SKP1-related A, isoform C) (SKP1-related A, isoform E) (SKP1-related A, isoform F) (SKP1-related A, isoform G) (SKPA)
Gene: SkpA

Interactor 2: Q9VDE3 (Q9VDE3)
LD08669p (Slimb) (Supernumerary limbs, isoform A) (Supernumerary limbs, isoform C)
Gene: slmb

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	25533207, 14605208, 15575970, 23747190, 24068890, 15710747, 22036573, 19084407, 19171756
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 162 Dm			1 510
+	Dm
		218244 O77430_DROME (1-162): 1.06e-83: 245: 100.00		O44382_DROME (1-510): 3.9e-151: 443: 99.61
+	Dm
		1180601 Q7KJ69_DROME (1-162): 3.39e-76: 225: 72.22		Q9VDE3_DROME (1-510): 4.65e-151: 443: 100.00
+	Ce
		105479 SKR1_CAEEL (4-161): 5.8e-79: 233: 63.35		SEL10_CAEEL (268-509): 3.52e-56: 198: 31.60
+	Sp
		953229 SKP1_SCHPO (1-162): 1.27e-74: 221: 56.10		POF1_SCHPO (276-508): 3.18e-59: 207: 27.54
+	Hs
		929125 SKP1_HUMAN (1-162): 4.55e-84: 245: 76.69		FBW1A_HUMAN (322-510): 1e-49: 182: 30.69
+	Mm
		1112932 SKP1_MOUSE (1-162): 2.52e-84: 246: 76.07		FBW1A_MOUSE (322-510): 1.14e-48: 178: 31.22
+	Xl
		1174984 SKP1_XENLA (1-162): 4.55e-84: 245: 76.69		TRCB_XENLA (322-510): 5.55e-49: 178: 31.22
+	Mm
		1131317 SKP1_MOUSE (1-162): 2.52e-84: 246: 76.07		FBW1B_MOUSE (322-510): 1.87e-48: 176: 31.22
+	Hs
		929110 SKP1_HUMAN (1-162): 4.55e-84: 245: 76.69		FBW1B_HUMAN (322-510): 2.18e-48: 176: 30.69
+	Dm
		285042 O77430_DROME (1-162): 1.06e-83: 245: 100.00		FBXW7_DROME (358-510): 1.47e-38: 152: 28.57
+	Mm
		1257397 SKP1_MOUSE (1-162): 2.52e-84: 246: 76.07		FBXW7_MOUSE (358-510): 1.04e-37: 149: 28.57
+	Hs
		929021 SKP1_HUMAN (1-162): 4.55e-84: 245: 76.69		FBXW7_HUMAN (358-510): 1.82e-37: 148: 28.57
+	Sp
		1000009 SKP1_SCHPO (1-162): 1.27e-74: 221: 56.10		POF11_SCHPO (45-320): 1.47e-39: 151: 20.43
+	Hs
		928946 SKP1_HUMAN (1-162): 4.55e-84: 245: 76.69		FBW10_HUMAN (337-490): 1.1e-27: 119: 23.00
+	Sp
		144900 SKP1_SCHPO (1-162): 1.27e-74: 221: 56.10		POP2_SCHPO (336-510): 8.21e-35: 140: 24.26
+	Hs
		929116 SKP1_HUMAN (1-162): 4.55e-84: 245: 76.69		FBXW2_HUMAN (366-502): 1.75e-24: 107: 27.34
+	Mm
		1351515 SKP1_MOUSE (1-162): 2.52e-84: 246: 76.07		Q9QUH1_MOUSE (366-502): 4.15e-23: 103: 26.62
+	Hs
		928956 SKP1_HUMAN (1-162): 4.55e-84: 245: 76.69		TRAF7_HUMAN (203-315): 9.52e-22: 100: 29.06
+	Sc
		431143 SKP1_YEAST (2-162): 7.49e-67: 203: 40.10		CDC4_YEAST (408-509): 6.11e-20: 95.3: 25.00
+	Sp
		953235 SKP1_SCHPO (1-162): 1.27e-74: 221: 56.10		POP1_SCHPO (416-509): 1.42e-13: 75.3: 19.15