HitPredict

Interactor 1: HCN1 (O88704)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2)
Gene: HCN1

Interactor 2: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	27507650, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045211 - postsynaptic membrane GO:0098978 - glutamatergic synapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 910 Mm			1 1730
+	Mm
		292106 HCN2_MOUSE (6-787): 0: 568: 61.66		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		239969 HCN1_HUMAN (1-910): 0: 666: 90.24		ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01
+	Hs
		240079 HCN1_HUMAN (1-910): 0: 666: 90.24		MIB1_HUMAN (187-625): 7.14e-50: 195: 10.66
+	Hs
		166861 HCN1_HUMAN (1-910): 0: 666: 90.24		ANR28_HUMAN (224-592): 3.91e-43: 174: 14.60
+	Hs
		239946 HCN1_HUMAN (1-910): 0: 666: 90.24		ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64
+	Hs
		240253 HCN1_HUMAN (1-910): 0: 666: 90.24		KDIS_HUMAN (258-430): 1.28e-21: 105: 16.19
+	Hs
		240315 HCN1_HUMAN (1-910): 0: 666: 90.24		PCLO_HUMAN (347-1361): 2.55e-17: 91.3: 10.90