HitPredict

Interactor 1: KLH18 (O94889)
Kelch-like protein 18
Gene: KLHL18

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	23213400, 28514442, 33292627, 33961781, 33130828, 34878901, 35563538, 21145461, 19295130, 34591642
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0016567 - protein ubiquitination GO:1901992 - positive regulation of mitotic cell cycle phase transition
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 574 Hs			1 768
+	Hs
		1042881 KLH20_HUMAN (15-570): 2.14e-176: 513: 42.55		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Rn
		78189 KLH17_RAT (7-572): 2.52e-164: 484: 42.76		CUL3_RAT (1-768): 0: 951: 99.61
+	Hs
		1041852 KLH17_HUMAN (7-572): 5.56e-164: 483: 42.76		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041718 KLH26_HUMAN (14-572): 2.25e-161: 475: 28.87		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042720 KLHL8_HUMAN (3-572): 6.73e-160: 472: 34.90		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042489 KLHL4_HUMAN (14-571): 4.5e-156: 465: 37.41		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041807 KLH10_HUMAN (26-573): 1.28e-155: 460: 31.03		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Dm
		1151465 Q6GKZ1_DROME (21-566): 0: 543: 27.40		Q8IP45_DROME (17-768): 0: 868: 69.08
+	Mm
		1322059 KLH10_MOUSE (26-573): 1.48e-154: 458: 30.85		CUL3_MOUSE (1-768): 0: 949: 99.48
+	Dm
		1151468 Q6GKZ1_DROME (21-566): 0: 543: 27.40		Q9V475_DROME (2-768): 0: 861: 68.77
+	Dm
		1213852 KLHDB_DROME (7-570): 1.61e-171: 501: 41.59		Q8IP45_DROME (17-768): 0: 868: 69.08
+	Hs
		1041986 KLHL7_HUMAN (26-551): 4.42e-96: 306: 33.58		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Rn
		70072 KLH17_RAT (7-572): 2.52e-164: 484: 42.76		B1WBY1_RAT (17-768): 0: 709: 30.53
+	Hs
		1041189 KLHL4_HUMAN (14-571): 4.5e-156: 465: 37.41		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1042324 KLHL5_HUMAN (364-572): 4.37e-59: 211: 38.28		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042624 KLHL1_HUMAN (369-571): 9.15e-58: 208: 36.45		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042964 NS1BP_HUMAN (197-459): 2.34e-51: 188: 29.17		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		299529 KLH18_HUMAN (1-574): 9.48e-176: 510: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Mm
		1225041 KLHL2_MOUSE (259-430): 1.24e-36: 146: 43.10		CUL3_MOUSE (1-768): 0: 949: 99.48
+	Dm
		1213843 Q9VGE5_DROME (383-571): 3.02e-53: 192: 38.42		Q8IP45_DROME (17-768): 0: 868: 69.08