HitPredict

Interactor 1: PRP6 (O94906)
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)
Gene: PRPF6

Interactor 2: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33022573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	TPR_16~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 941 Hs			1 334
+	Hs
		300167 PRP6_HUMAN (1-941): 0: 610: 100.00		SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71
+	Hs
		300222 PRP6_HUMAN (1-941): 0: 610: 100.00		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		300229 PRP6_HUMAN (1-941): 0: 610: 100.00		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		196929 PRP6_HUMAN (1-941): 0: 610: 100.00		PRP4_HUMAN (244-333): 1.12e-10: 64.2: 19.39
+	Hs
		903230 RRP5_HUMAN (474-761): 1.34e-26: 120: 14.09		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		174768 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		209476 CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50		PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05
+	Hs
		1310798 CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50		WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83
+	Dm
		54179 SYF1_DROME (229-527): 1.98e-12: 73.4: 15.24		Q9VYQ9_DROME (12-333): 2.1e-89: 277: 26.67
+	Hs
		209486 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05
+	Dm
		571971 CRN_DROME (271-568): 1.36e-17: 90: 14.33		Q9VPL0_DROME (1-285): 1.56e-79: 247: 23.15
+	Hs
		1310806 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83
+	Hs
		175177 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28
+	Hs
		1058048 RRP5_HUMAN (474-761): 1.34e-26: 120: 14.09		NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54
+	Hs
		1288293 CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		1199241 PRP39_HUMAN (425-927): 1.16e-23: 109: 15.92		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Sp
		224207 CYC8_SCHPO (224-402): 4.47e-13: 75.7: 13.83		TUP11_SCHPO (3-117): 1.07e-31: 126: 25.19
+	Sp
		224208 CYC8_SCHPO (224-402): 4.47e-13: 75.7: 13.83		TUP12_SCHPO (2-118): 1.15e-30: 123: 20.30
+	Hs
		1058000 RRP5_HUMAN (474-761): 1.34e-26: 120: 14.09		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		1288323 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29