HitPredict

Interactor 1: NFAT5 (O94916)
Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP)
Gene: NFAT5

Interactor 2: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	11485737, 16027109
Identification Methods	anti tag coimmunoprecipitation, DNase I footprinting
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010628 - positive regulation of gene expression GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1904996 - positive regulation of leukocyte adhesion to vascular endothelial cell
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 233
+	Mm
		420412 NFAT5_MOUSE (1-1531): 0: 1965: 91.35		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Hs
		352606 NFAC2_HUMAN (267-828): 1.07e-134: 442: 27.16		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Mm
		420392 NFKB1_MOUSE (269-780): 9.71e-149: 481: 15.46		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Hs
		352598 NFAC3_HUMAN (267-752): 5.82e-116: 394: 31.61		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		352617 NFAC4_HUMAN (267-648): 2.7e-113: 382: 32.66		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		317883 NFAC1_HUMAN (267-828): 3.65e-111: 377: 28.77		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		352584 RELB_HUMAN (269-709): 1.58e-113: 373: 16.50		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		352589 TF65_HUMAN (268-681): 1.89e-112: 368: 16.15		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Mm
		78126 B5B2U4_MOUSE (267-752): 1.46e-113: 387: 32.21		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Mm
		420397 TF65_MOUSE (268-774): 2.34e-115: 376: 15.96		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Mm
		420398 RELB_MOUSE (269-707): 8.11e-114: 373: 17.23		TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81
+	Hs
		669883 NFAC2_HUMAN (267-828): 1.07e-134: 442: 27.16		CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49
+	Hs
		155683 NFAC3_HUMAN (267-752): 5.82e-116: 394: 31.61		TNF11_HUMAN (52-233): 5.98e-50: 167: 18.14
+	Hs
		317913 NFAC1_HUMAN (267-828): 3.65e-111: 377: 28.77		CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49
+	Hs
		669879 REL_HUMAN (275-813): 3.56e-108: 359: 14.65		CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49