HitPredict

Interactor 1: KDM4B (O94953)
Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B)
Gene: KDM4B

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30418174, 21502505
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1096 Hs			1 595
+	Mm
		587108 KDM4B_MOUSE (1-1096): 0: 1051: 77.98		ESR1_MOUSE (1-595): 0: 570: 88.98
+	Hs
		301151 KDM4B_HUMAN (1-1096): 0: 1150: 100.00		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Mm
		587107 KDM4C_MOUSE (4-1087): 0: 971: 52.41		ESR1_MOUSE (1-595): 0: 570: 88.98
+	Mm
		587106 KDM4A_MOUSE (1-1083): 0: 951: 49.42		ESR1_MOUSE (1-595): 0: 570: 88.98
+	Mm
		580484 KDM4C_MOUSE (4-1087): 0: 971: 52.41		ANDR_MOUSE (32-555): 1.51e-102: 332: 22.04
+	Hs
		740598 KDM4C_HUMAN (3-1087): 0: 967: 52.51		PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35
+	Hs
		256937 KDM4A_HUMAN (1-1083): 0: 944: 48.89		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		876710 BRPF1_HUMAN (477-1092): 3.03e-92: 323: 19.05		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		487518 KDM4D_HUMAN (1-505): 2.9e-175: 525: 53.73		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		369044 KDM5A_HUMAN (5-57): 8.55e-12: 72: 33.96		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		510043 BRPF3_HUMAN (486-1094): 4.39e-88: 311: 17.40		ERR1_HUMAN (123-547): 6.94e-103: 319: 34.04
+	Hs
		666545 KDM5A_HUMAN (5-57): 8.55e-12: 72: 33.96		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		500378 KDM5B_HUMAN (6-75): 3.98e-12: 73.2: 28.57		RARB_HUMAN (111-579): 7.62e-114: 349: 22.47
+	Hs
		377116 KDM5A_HUMAN (5-57): 8.55e-12: 72: 33.96		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Mm
		1113373 KDM5A_MOUSE (5-57): 8.77e-12: 72: 33.96		ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42
+	Hs
		487907 KDM5A_HUMAN (5-57): 8.55e-12: 72: 33.96		RARA_HUMAN (81-545): 1.35e-102: 320: 22.37
+	Hs
		487739 KDM5D_HUMAN (5-97): 7.96e-14: 78.6: 24.73		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		1267477 KDM5B_HUMAN (6-75): 3.98e-12: 73.2: 28.57		NR4A3_HUMAN (185-534): 1.48e-37: 149: 30.70
+	Hs
		487816 KDM5B_HUMAN (6-75): 3.98e-12: 73.2: 28.57		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16