Protein: Q9VXK5
Putative rRNA methyltransferase (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase SPB1 homolog)

Gene: Q9VXK5, dSpb1
Organism: Drosophila melanogaster
Interactions: 87
UniProt ID: Q9VXK5

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005730 - nucleolus
GO:0008650 - rRNA (uridine-2'-O-)-methyltransferase activity
GO:0016435 - rRNA (guanine) methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1264482

BOP1
Ribosome biogenesis protein BOP1 homolog

2

8

High-throughput

0.737

High

1266328

Q7K4B2
LD47540p

2

5

High-throughput

0.737

High

1474949

RLP24
Probable ribosome biogenesis protein RLP24

2

3

High-throughput

0.737

High

1477268

NOC3L
Nucleolar complex protein 3

2

4

High-throughput

0.737

High

54915

A1Z909
LD11307p

2

5

High-throughput

0.571

High

304822

O76994
Ribosome biogenesis protein NSA2 homolog

2

2

High-throughput

0.571

High

1261367

Q7JQN4
RNA helicase

2

8

High-throughput

0.571

High

1263260

Q7JXU4
Nucleolar GTP-binding protein 2

2

7

High-throughput

0.571

High

1321635

GNL3
Guanine nucleotide-binding protein-like 3 homolog

2

7

High-throughput

0.571

High

1344164

Q8SY39
ATP-dependent RNA helicase DDX54

2

8

High-throughput

0.571

High

1378658

Q95WY3
Nucleolar protein 56

2

4

High-throughput

0.571

High

1464959

NOG1
Nucleolar GTP-binding protein 1

2

7

High-throughput

0.571

High

1470890

Q9VCY1
RRM domain-containing protein

2

4

High-throughput

0.571

High

1471263

DDX18
Probable ATP-dependent RNA helicase pitchoune

2

12

High-throughput

0.571

High

1471899

SURF6
Surfeit locus protein 6 homolog

2

1

High-throughput

0.571

High

1477475

DDX47
ATP-dependent RNA helicase DDX47

2

12

High-throughput

0.571

High

1479361

RPF1
Probable ribosome production factor 1

2

3

High-throughput

0.571

High

1479375

Q9VKC1
IP16805p

2

4

High-throughput

0.571

High

1481554

Q9VM69
Nucleolar protein 58

2

4

High-throughput

0.571

High

1488298

Q9W3B2
Protein MAK16 homolog

2

2

High-throughput

0.571

High

1488300

NOP53
Ribosome biogenesis protein NOP53

2

3

High-throughput

0.571

High

1488291

RRP12
RRP12-like protein

2

0

High-throughput

0.547

High

1488299

NAT10
RNA cytidine acetyltransferase

2

0

High-throughput

0.547

High

356920

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

2

3

High-throughput

0.521

High

1471694

Q9VDK7
Signal recognition particle subunit SRP72

2

1

High-throughput

0.521

High

1472789

Q9VEH0
Aluminum tubes, isoform A

2

9

High-throughput

0.521

High

1478885

RRP1L
Ribosomal RNA processing protein 1 homolog

2

4

High-throughput

0.521

High

1488294

Q9VZF5
Kinesin-like protein

2

3

High-throughput

0.521

High

856167

MOEH
Moesin/ezrin/radixin homolog 1

1

3

High-throughput

0.494

High

1069423

Q0E8K8
FI21816p1

1

4

High-throughput

0.489

High

1344687

Q8SYU5
RE33762p

1

4

High-throughput

0.489

High

1440346

Q9I7K8
FI07222p

1

4

High-throughput

0.489

High

929438

FKB39
39 kDa FK506-binding nuclear protein

1

2

Small-scale

0.479

High

1237385

Q6NQY9
ATP-dependent RNA helicase

1

8

High-throughput

0.445

High

1268875

NHK1
Nucleosomal histone kinase 1

1

1

High-throughput

0.445

High

1302249

Q8I937
Ribosome biogenesis regulatory protein

1

3

High-throughput

0.445

High

1467206

EBP2
Probable rRNA-processing protein EBP2 homolog

1

1

High-throughput

0.445

High

1471504

PPAN
Protein Peter pan

1

2

High-throughput

0.445

High

1472569

RPF2
Ribosome production factor 2 homolog

1

2

High-throughput

0.445

High

1478454

Q9VJG2
RRM domain-containing protein

1

6

High-throughput

0.445

High

1480580

PESC
Pescadillo homolog

1

2

High-throughput

0.445

High

1484904

Q9VRI0
Probable ATP-dependent RNA helicase DDX56

1

11

High-throughput

0.445

High

1485781

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.445

High

1488292

Q9VZ88
AT07585p

1

9

High-throughput

0.445

High

1488293

BRX1
Ribosome biogenesis protein BRX1 homolog

1

6

High-throughput

0.445

High

1488297

Q9W124
LD27920p

1

4

High-throughput

0.445

High

120402

M9PD17
Gigas, isoform B

1

3

High-throughput

0.437

High

1267796

Q7KMQ6
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

High-throughput

0.437

High

1470247

Q9VCC9
LD23779p

1

7

High-throughput

0.437

High

892992

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.426

High

1467060

Q9V9U9
Nucleolar protein 16

1

0

High-throughput

0.426

High

1473791

RRP15
RRP15-like protein

1

0

High-throughput

0.426

High

55836

A1Z9K0
Uncharacterized protein, isoform B

1

3

High-throughput

0.407

High

263237

TENM
Teneurin-m

1

2

High-throughput

0.407

High

264455

O62530
Adaptor protein complex 2, mu subunit, isoform A

1

2

High-throughput

0.407

High

451931

NOTCH
Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]

1

1

High-throughput

0.407

High

614427

SGG
Protein kinase shaggy

1

6

High-throughput

0.407

High

823808

SQH
Myosin regulatory light chain sqh

1

1

High-throughput

0.407

High

834884

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

1

High-throughput

0.407

High

911797

POLO
Serine/threonine-protein kinase polo

1

4

High-throughput

0.407

High

1069784

Q0E931
GTP-binding protein 1

1

7

High-throughput

0.407

High

1216862

Q5U156
RE01954p

1

3

High-throughput

0.407

High

1234137

SARM1
NAD(+) hydrolase sarm1

1

2

High-throughput

0.407

High

1266525

Q7K4L8
RNA helicase

1

4

High-throughput

0.407

High

1303837

Q8INH9
Uncharacterized protein, isoform J

1

4

High-throughput

0.407

High

1466893

Q9V9S0
FI04419p

1

1

High-throughput

0.407

High

1468549

LARP
La-related protein 1

1

4

High-throughput

0.407

High

1477173

Q9VI53
LD44267p

1

4

High-throughput

0.407

High

1480797

Y3096
Ribosomal L1 domain-containing protein CG13096

1

7

High-throughput

0.407

High

1486099

Q9VTF8
Mitochondrial ribosomal protein L2

1

2

High-throughput

0.407

High

1488290

Q9VXR5
ATP-binding cassette sub-family F member 2

1

2

High-throughput

0.407

High

1488295

Q9W0R0
Cell division cycle 5, isoform A

1

3

High-throughput

0.407

High

1473051

Q9VEP0
Regulatory protein zeste

2

0

High-throughput

0.298

High

1484222

Q9VQI5
Interferon-related developmental regulator 1

2

0

High-throughput

0.298

High

1479533

ZUC
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1488303

4EBP
Eukaryotic translation initiation factor 4E-binding protein

1

0

High-throughput

0.249

Low

95268

E1JIH4
Uncharacterized protein, isoform D

1

0

High-throughput

0.232

Low

360603

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.232

Low

909888

PFKA
ATP-dependent 6-phosphofructokinase

1

0

High-throughput

0.232

Low

1059191

ROP
Protein ROP

1

0

High-throughput

0.232

Low

1285826

Q86BS3
Chromator, isoform A

1

0

High-throughput

0.232

Low

1321470

Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.232

Low

1482319

Q9VN39
RE74585p

1

0

High-throughput

0.232

Low

1486665

FRL
Formin-like protein

1

0

High-throughput

0.232

Low

1488296

Q9W0T7
Dis3 like 3'-5' exoribonuclease 2, isoform A

1

0

High-throughput

0.232

Low

1488301

Q9W4C4
GM14014p

1

0

High-throughput

0.232

Low

1488302

Q9XZ53
dolichyl-diphosphooligosaccharide--protein glycotransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025