HitPredict

Interactor 1: M3K6 (O95382)
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)
Gene: MAP3K6

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1288 Hs			1 724
+	Hs
		312772 M3K6_HUMAN (1-1288): 0: 1354: 99.38		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438465 M3K5_HUMAN (2-1282): 0: 1194: 44.40		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438288 M3K15_HUMAN (2-1278): 0: 1186: 43.56		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		432196 M3K5_HUMAN (2-1282): 0: 1194: 44.40		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431980 M3K15_HUMAN (2-1278): 0: 1186: 43.56		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		312798 M3K6_HUMAN (1-1288): 0: 1354: 99.38		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		437962 KPCI_HUMAN (446-976): 1.46e-126: 405: 18.25		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438190 KS6A2_HUMAN (644-1151): 6.06e-125: 405: 19.31		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438011 KS6A3_HUMAN (576-1151): 9.14e-121: 394: 17.58		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431621 KPCI_HUMAN (446-976): 1.46e-126: 405: 18.25		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431873 KS6A2_HUMAN (644-1151): 6.06e-125: 405: 19.31		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438193 KS6A1_HUMAN (576-1148): 1.37e-118: 388: 18.01		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438601 KS6A6_HUMAN (610-1151): 6.5e-117: 384: 17.36		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431672 KS6A3_HUMAN (576-1151): 9.14e-121: 394: 17.58		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431876 KS6A1_HUMAN (576-1148): 1.37e-118: 388: 18.01		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		432343 KS6A6_HUMAN (610-1151): 6.5e-117: 384: 17.36		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		270363 KS6A5_HUMAN (630-1137): 3.6e-112: 372: 19.25		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Sc
		543156 YPK2_YEAST (367-984): 5.22e-139: 441: 16.14		HSC82_YEAST (13-724): 0: 922: 60.22
+	Sc
		365679 YPK1_YEAST (366-982): 2.8e-126: 407: 16.30		HSP82_YEAST (12-724): 0: 927: 61.26
+	Sc
		520572 YPK1_YEAST (366-982): 2.8e-126: 407: 16.30		HSC82_YEAST (13-724): 0: 922: 60.22