HitPredict

Interactor 1: M3K6 (O95382)
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)
Gene: MAP3K6

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	33961781, 19935702, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1288 Hs			1 247
+	Hs
		312790 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		312793 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		312780 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		312792 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		312777 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		312781 M3K6_HUMAN (1-1288): 0: 1354: 99.38		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		909955 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		905034 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		909709 M3K15_HUMAN (2-1278): 0: 1186: 43.56		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		982422 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		982174 M3K15_HUMAN (2-1278): 0: 1186: 43.56		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		683661 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		927451 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		927194 M3K15_HUMAN (2-1278): 0: 1186: 43.56		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		647219 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		684290 M3K5_HUMAN (2-1282): 0: 1194: 44.40		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		159186 CSKP_HUMAN (648-1288): 4.4e-132: 430: 16.86		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		683485 MARK2_HUMAN (596-1261): 5.09e-129: 418: 14.12		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		647041 MARK2_HUMAN (596-1261): 5.09e-129: 418: 14.12		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		684157 MARK2_HUMAN (596-1261): 5.09e-129: 418: 14.12		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16