HitPredict

Interactor 1: HCN1 (O88704)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2)
Gene: HCN1

Interactor 2: HCN1 (O88704)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2)
Gene: HCN1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.51 1.00 0.716

The method score is based on:

Property Details
Experiments 22006928
Identification Methods molecular sieving, cosedimentation in solution, dynamic light scattering
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains cNMP_binding~cNMP_binding, Ion_trans~cNMP_binding, Ion_trans_N~cNMP_binding, Ion_trans~Ion_trans, Ion_trans~Ion_trans_N
Common GO terms GO:0003254 - regulation of membrane depolarization
GO:0005222 - intracellularly cAMP-activated cation channel activity
GO:0005248 - voltage-gated sodium channel activity
GO:0005249 - voltage-gated potassium channel activity
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
and 32 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 910
Mm

1 910
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Service provided by Combinatics, Japan

Last updated: 11Aug2025