Protein: KCNH2
Voltage-gated inwardly rectifying potassium channel KCNH2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1)

Gene: KCNH2
Organism: Homo sapiens
Interactions: 43
UniProt ID: Q12809

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0003064 - regulation of heart rate by hormone
GO:0005242 - inward rectifier potassium channel activity
GO:0005249 - voltage-gated potassium channel activity
GO:0005251 - delayed rectifier potassium channel activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1086462

KCNH2
Voltage-gated inwardly rectifying potassium channel KCNH2

4

15

Small-scale

0.896

High

1086471

AN13D
Ankyrin repeat domain-containing protein 13D

1

2

High-throughput

0.691

High

1086475

MIB2
E3 ubiquitin-protein ligase MIB2

1

5

High-throughput

0.691

High

1086484

KCNH7
Voltage-gated inwardly rectifying potassium channel KCNH7

1

15

High-throughput

0.691

High

461409

HS90A
Heat shock protein HSP 90-alpha

4

2

Small-scale

0.683

High

583934

KCNE1
Potassium voltage-gated channel subfamily E member 1

1

2

Small-scale

0.618

High

1086486

KCND3
A-type voltage-gated potassium channel KCND3

1

3

Small-scale

0.618

High

1086480

FRMD8
FERM domain-containing protein 8

2

1

High-throughput

0.606

High

537059

HSP7C
Heat shock cognate 71 kDa protein

2

2

Small-scale

0.601

High

1086470

RN207
RING finger protein 207

2

2

Small-scale

0.584

High

1086476

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

3

Small-scale

0.584

High

1086487

CHIP
E3 ubiquitin-protein ligase CHIP

2

2

Small-scale

0.584

High

971454

1433E
14-3-3 protein epsilon

1

8

Small-scale

0.573

High

1086482

TARA
TRIO and F-actin-binding protein

1

8

Small-scale

0.573

High

698614

CALX
Calnexin

2

1

Small-scale

0.549

High

1086463

CUL1
Cullin-1

1

1

High-throughput

0.536

High

1086483

JPH1
Junctophilin-1

1

2

High-throughput

0.536

High

761652

HSP74
Heat shock 70 kDa protein 4

2

3

Small-scale

0.533

High

976232

RB11A
Ras-related protein Rab-11A

1

0

Small-scale

0.517

High

727773

DNJA1
DnaJ homolog subfamily A member 1

1

1

Small-scale

0.515

High

1086477

PASK
PAS domain-containing serine/threonine-protein kinase

1

11

Small-scale

0.514

High

1086478

SMAD5
Mothers against decapentaplegic homolog 5

1

0

High-throughput

0.513

High

1086467

Q6ICP4
Rho-related GTP-binding protein RhoH

1

0

High-throughput

0.494

High

346984

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.493

High

411826

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

697861

CALR
Calreticulin

1

1

Small-scale

0.479

High

941344

CAV3
Caveolin-3

1

3

Small-scale

0.479

High

1086474

RFFL
E3 ubiquitin-protein ligase rififylin

1

4

Small-scale

0.479

High

1086464

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

Small-scale

0.470

High

1086466

AG10B
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

0

Small-scale

0.458

High

1086472

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.458

High

1041028

CAV1
Caveolin-1

1

3

Small-scale

0.457

High

327973

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.445

High

1086481

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.445

High

1086473

RN139
E3 ubiquitin-protein ligase RNF139

1

2

Small-scale

0.437

High

278656

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.282

High

1086468

CDC73
Parafibromin

1

0

High-throughput

0.282

High

1086465

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

1086469

KLD10
Kelch domain-containing protein 10

1

0

High-throughput

0.279

Low

1086485

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

731239

STIP1
Stress-induced-phosphoprotein 1

1

0

Small-scale

0.269

Low

1086479

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025