HitPredict

Interactor 1: CBX6 (O95503)
Chromobox protein homolog 6
Gene: CBX6

Interactor 2: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	24981860, 33961781, 21282530
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 259
+	Hs
		315976 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Mm
		1164651 Q6TKP2_MOUSE (1-393): 6.6e-135: 403: 86.58		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Hs
		315977 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		316045 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Mm
		1321737 CBX6_MOUSE (1-393): 3.2e-126: 372: 88.86		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Hs
		316144 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		316077 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		PCGF5_HUMAN (30-257): 3.38e-44: 151: 29.41
+	Hs
		316133 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		316019 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Dr
		1186372 Q804D1_DANRE (1-385): 1.19e-77: 250: 24.21		BMI1B_DANRE (30-255): 6.8e-65: 207: 36.44
+	Mm
		639481 CBX8_MOUSE (1-393): 7.89e-80: 252: 32.43		BMI1_MOUSE (30-255): 1.56e-62: 200: 35.59
+	Dr
		1193374 Q804D1_DANRE (1-385): 1.19e-77: 250: 24.21		BMI1A_DANRE (30-255): 2.14e-61: 197: 35.59
+	Hs
		718213 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Mm
		620795 CBX8_MOUSE (1-393): 7.89e-80: 252: 32.43		PCGF2_MOUSE (30-255): 2.33e-56: 185: 35.98
+	Hs
		718431 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		1108545 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Mm
		1321744 CBX8_MOUSE (1-393): 7.89e-80: 252: 32.43		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Dr
		1193367 Q804D1_DANRE (1-385): 1.19e-77: 250: 24.21		RING2_DANRE (24-259): 5.59e-38: 137: 16.56
+	Mm
		193417 CBX8_MOUSE (1-393): 7.89e-80: 252: 32.43		RING1_MOUSE (24-155): 5.39e-33: 125: 20.59
+	Hs
		988024 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59