Protein: RECQ5
ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)

Gene: RECQ5, RECQL5
Organism: Homo sapiens
Interactions: 110
UniProt ID: O94762

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000724 - double-strand break repair via homologous recombination
GO:0000993 - RNA polymerase II complex binding
GO:0003677 - DNA binding
GO:0003678 - DNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

316252

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

5

Small-scale

0.886

High

316257

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

1

Small-scale

0.886

High

316254

RPB1
DNA-directed RNA polymerase II subunit RPB1

8

10

Small-scale

0.753

High

316274

RPB7
DNA-directed RNA polymerase II subunit RPB7

7

2

Small-scale

0.747

High

316323

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

5

8

High-throughput

0.716

High

316253

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

1

Small-scale

0.699

High

316298

DDX42
ATP-dependent RNA helicase DDX42

1

17

High-throughput

0.698

High

316234

RECQ5
ATP-dependent DNA helicase Q5

1

19

Small-scale

0.692

High

316326

ASB6
Ankyrin repeat and SOCS box protein 6

1

5

High-throughput

0.691

High

192766

RPB4
DNA-directed RNA polymerase II subunit RPB4

4

0

Small-scale

0.674

High

305821

DXO
Decapping and exoribonuclease protein

3

1

High-throughput

0.667

High

316283

RAD51
DNA repair protein RAD51 homolog 1

3

14

Small-scale

0.660

High

131635

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

12

Small-scale

0.656

High

316260

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

3

Small-scale

0.656

High

316277

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

3

1

High-throughput

0.650

High

316248

PCNA
Proliferating cell nuclear antigen

2

6

Small-scale

0.639

High

316255

RBTN2
Rhombotin-2

2

4

High-throughput

0.628

High

316246

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

4

0

High-throughput

0.623

High

316270

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.622

High

314966

RECQ4
ATP-dependent DNA helicase Q4

1

18

Small-scale

0.618

High

316240

TOP3B
DNA topoisomerase 3-beta-1

1

10

Small-scale

0.618

High

316287

TOP3A
DNA topoisomerase 3-alpha

1

10

Small-scale

0.618

High

316302

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

316307

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

19

High-throughput

0.618

High

316312

DDX23
Probable ATP-dependent RNA helicase DDX23

1

16

High-throughput

0.618

High

316325

NLE1
Notchless protein homolog 1

1

13

High-throughput

0.618

High

316273

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.602

High

262461

MCE1
mRNA-capping enzyme

2

3

High-throughput

0.584

High

316261

BRCA1
Breast cancer type 1 susceptibility protein

2

20

High-throughput

0.584

High

316279

H31
Histone H3.1

2

18

High-throughput

0.584

High

316243

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

316311

MED10
Mediator of RNA polymerase II transcription subunit 10

2

1

High-throughput

0.571

High

261988

NBN
Nibrin

1

4

Small-scale

0.561

High

316267

MRE11
Double-strand break repair protein MRE11

1

3

Small-scale

0.561

High

316305

RAD50
DNA repair protein RAD50

1

11

Small-scale

0.561

High

213505

MTSS1
Protein MTSS 1

1

10

High-throughput

0.541

High

316250

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.541

High

316256

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.541

High

316262

CUX1
Homeobox protein cut-like 1

1

15

High-throughput

0.541

High

316271

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.541

High

316331

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

3

High-throughput

0.541

High

316309

MUS81
Structure-specific endonuclease subunit MUS81

1

0

Small-scale

0.537

High

316249

FOSL2
Fos-related antigen 2

1

3

High-throughput

0.536

High

316280

SRPK2
SRSF protein kinase 2

1

15

High-throughput

0.536

High

316306

CUL5
Cullin-5

1

20

High-throughput

0.536

High

316310

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

8

High-throughput

0.536

High

316316

PAR6B
Partitioning defective 6 homolog beta

1

1

High-throughput

0.536

High

316318

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

13

High-throughput

0.536

High

316286

CENPR
Centromere protein R

1

0

High-throughput

0.518

High

316317

PITH1
PITH domain-containing protein 1

1

0

High-throughput

0.513

High

316241

TIMP1
Metalloproteinase inhibitor 1

1

2

High-throughput

0.494

High

316328

FBLN5
Fibulin-5

1

5

High-throughput

0.489

High

130334

SPT5H
Transcription elongation factor SPT5

1

13

High-throughput

0.479

High

140690

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

316235

UBR5
E3 ubiquitin-protein ligase UBR5

1

15

Small-scale

0.479

High

316236

SCAF4
SR-related and CTD-associated factor 4

1

5

High-throughput

0.479

High

316238

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

10

Small-scale

0.479

High

316242

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

316244

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.479

High

316247

TOP1
DNA topoisomerase 1

1

5

Small-scale

0.479

High

316251

NUCL
Nucleolin

1

10

Small-scale

0.479

High

316258

MCM7
DNA replication licensing factor MCM7

1

14

Small-scale

0.479

High

316259

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

316263

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

316264

YAP1
Transcriptional coactivator YAP1

1

20

Small-scale

0.479

High

316266

RBP2
E3 SUMO-protein ligase RanBP2

1

11

Small-scale

0.479

High

316269

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

316275

H4
Histone H4

1

8

High-throughput

0.479

High

316276

H2B1C
Histone H2B type 1-C/E/F/G/I

1

13

High-throughput

0.479

High

316278

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.479

High

316281

PRKDC
DNA-dependent protein kinase catalytic subunit

1

11

Small-scale

0.479

High

316282

H33
Histone H3.3

1

18

High-throughput

0.479

High

316284

TP53B
TP53-binding protein 1

1

8

High-throughput

0.479

High

316285

TIF1B
Transcription intermediary factor 1-beta

1

19

Small-scale

0.479

High

316290

MDC1
Mediator of DNA damage checkpoint protein 1

1

19

High-throughput

0.479

High

316291

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

316292

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

14

High-throughput

0.479

High

316296

SPT6H
Transcription elongation factor SPT6

1

1

High-throughput

0.479

High

316299

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

316300

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

316301

SLX4
Structure-specific endonuclease subunit SLX4

1

15

High-throughput

0.479

High

316304

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

316313

KLF16
Krueppel-like factor 16

1

7

High-throughput

0.479

High

316314

FACD2
Fanconi anemia group D2 protein

1

10

High-throughput

0.479

High

316315

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

18

High-throughput

0.479

High

316319

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.479

High

316320

SFR19
Splicing factor, arginine/serine-rich 19

1

15

High-throughput

0.479

High

316321

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.479

High

316324

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.479

High

316327

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

316329

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

316330

XPO7
Exportin-7

1

16

High-throughput

0.479

High

316332

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

316297

BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

1

0

High-throughput

0.460

High

316272

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

316288

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.458

High

316294

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

316308

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

316322

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

316265

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

2

High-throughput

0.457

High

316268

NCBP2
Nuclear cap-binding protein subunit 2

1

20

High-throughput

0.445

High

316289

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

3

High-throughput

0.445

High

316239

STABP
STAM-binding protein

1

0

High-throughput

0.438

High

136756

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

6

High-throughput

0.437

High

316295

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

316237

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.426

High

316245

MYZAP
Myocardial zonula adherens protein

1

7

High-throughput

0.407

High

316293

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

0

High-throughput

0.353

High

316303

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025