HitPredict

Interactor 1: KLF8 (O95600)
Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741)
Gene: KLF8

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35140242
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 488
+	Hs
		435149 SP1_HUMAN (90-358): 1.01e-66: 226: 30.48		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038377 ZN273_HUMAN (71-332): 8.53e-85: 269: 16.85		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		970932 SP3_HUMAN (44-358): 3.4e-51: 183: 22.10		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		250993 SP3_MOUSE (44-358): 3.99e-50: 180: 21.53		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		204206 KLF4_HUMAN (105-356): 4.72e-49: 174: 32.56		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1158943 ZFP1_HUMAN (199-358): 3.19e-46: 164: 17.12		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		435085 SP1_HUMAN (90-358): 1.01e-66: 226: 30.48		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1046724 KLF5_HUMAN (267-356): 1.18e-41: 152: 78.89		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		140212 SP1_MOUSE (63-358): 2.13e-62: 214: 27.39		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Mm
		140208 SP3_MOUSE (44-358): 3.99e-50: 180: 21.53		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		970913 SP3_HUMAN (44-358): 3.4e-51: 183: 22.10		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1032214 KLF1_HUMAN (87-356): 1.75e-50: 174: 30.28		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		204176 KLF4_HUMAN (105-356): 4.72e-49: 174: 32.56		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177170 SP1_HUMAN (90-358): 1.01e-66: 226: 30.48		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		140295 Q8BPQ2_MOUSE (270-356): 1.87e-43: 154: 75.86		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1038360 KLF5_HUMAN (267-356): 1.18e-41: 152: 78.89		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		292670 SP1_MOUSE (63-358): 2.13e-62: 214: 27.39		Q9JM08_MOUSE (10-431): 0: 568: 58.02
+	Hs
		177364 KLF6_HUMAN (225-356): 1.11e-45: 159: 58.33		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		1207125 Q8BPQ2_MOUSE (270-356): 1.87e-43: 154: 75.86		Q9JM08_MOUSE (10-431): 0: 568: 58.02
+	Hs
		204200 KLF4_HUMAN (105-356): 4.72e-49: 174: 32.56		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37