HitPredict

Interactor 1: EYA4 (O95677)
Eyes absent homolog 4 (EC 3.1.3.48)
Gene: EYA4

Interactor 2: CIC (Q96RK0)
Protein capicua homolog
Gene: CIC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29844126, 38360978
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 2517
+	Hs
		118599 EYA2_HUMAN (120-639): 0: 536: 57.12		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		967374 EWS_HUMAN (103-334): 1.19e-32: 135: 17.21		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		124053 SPT5H_HUMAN (5-259): 1.51e-12: 73.1: 12.26		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		867119 SC24C_HUMAN (23-362): 6.79e-12: 70.8: 10.63		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		318762 EYA4_HUMAN (1-639): 0: 650: 100.00		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Mm
		818695 EYA1_MOUSE (82-639): 1.16e-177: 519: 71.83		SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44
+	Hs
		118625 EYA2_HUMAN (120-639): 0: 536: 57.12		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Ce
		184765 EYA1_CAEEL (167-635): 6.6e-97: 308: 23.45		EGL13_CAEEL (1033-1238): 1.27e-41: 163: 20.00
+	Ce
		184732 EYA1_CAEEL (167-635): 6.6e-97: 308: 23.45		POP1_CAEEL (959-1182): 1.17e-34: 141: 22.17
+	Hs
		817937 EWS_HUMAN (103-334): 1.19e-32: 135: 17.21		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		123877 SPT5H_HUMAN (5-259): 1.51e-12: 73.1: 12.26		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		818266 KMT2C_HUMAN (17-365): 1.05e-10: 67.3: 9.52		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		727730 EWS_HUMAN (103-334): 1.19e-32: 135: 17.21		SOX5_HUMAN (833-1211): 2.27e-29: 129: 17.71
+	Hs
		967536 EWS_HUMAN (103-334): 1.19e-32: 135: 17.21		SOX21_HUMAN (1103-1192): 3.31e-29: 121: 34.44
+	Hs
		967173 EWS_HUMAN (103-334): 1.19e-32: 135: 17.21		MDC1_HUMAN (1380-2408): 4.76e-21: 104: 10.30
+	Hs
		967541 EWS_HUMAN (103-334): 1.19e-32: 135: 17.21		PCLO_HUMAN (512-2427): 1.81e-10: 69.1: 8.23
+	Hs
		967303 EWS_HUMAN (103-334): 1.19e-32: 135: 17.21		TITIN_HUMAN (609-1544): 3.51e-09: 65.2: 9.85
+	Hs
		124057 SPT5H_HUMAN (5-259): 1.51e-12: 73.1: 12.26		MINT_HUMAN (730-2515): 3e-28: 127: 9.45
+	Hs
		124137 SPT5H_HUMAN (5-259): 1.51e-12: 73.1: 12.26		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Mm
		1351630 PCLO_MOUSE (5-363): 2.78e-17: 88.9: 9.02		PCLO_MOUSE (548-2254): 8.86e-09: 63.7: 7.78