HitPredict

Interactor 1: HS74L (O95757)
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94)
Gene: HSPA4L

Interactor 2: ROS1 (P08922)
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Gene: ROS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 839 Hs			1 2347
+	Hs
		320817 HS74L_HUMAN (1-839): 0: 1032: 100.00		EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61
+	Hs
		320795 HS74L_HUMAN (1-839): 0: 1032: 100.00		INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13
+	Hs
		320797 HS74L_HUMAN (1-839): 0: 1032: 100.00		IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25
+	Hs
		1072565 HS105_HUMAN (1-839): 0: 925: 58.24		EPHA7_HUMAN (1385-2313): 1.98e-180: 581: 18.43
+	Hs
		665505 HS105_HUMAN (1-839): 0: 925: 58.24		EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61
+	Hs
		411458 HS105_HUMAN (1-839): 0: 925: 58.24		INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13
+	Hs
		320928 HS74L_HUMAN (1-839): 0: 1032: 100.00		ALK_HUMAN (1858-2311): 4.31e-84: 309: 38.96
+	Hs
		320811 HS74L_HUMAN (1-839): 0: 1032: 100.00		FGFR3_HUMAN (1886-2215): 4.22e-59: 222: 38.73
+	Hs
		1267783 HS105_HUMAN (1-839): 0: 925: 58.24		ALK_HUMAN (1858-2311): 4.31e-84: 309: 38.96
+	Hs
		426948 HSP74_HUMAN (1-839): 0: 931: 62.60		FES_HUMAN (1943-2219): 1.12e-60: 227: 42.60
+	Hs
		609191 HSP74_HUMAN (1-839): 0: 931: 62.60		FGFR3_HUMAN (1886-2215): 4.22e-59: 222: 38.73
+	Hs
		412053 HSP74_HUMAN (1-839): 0: 931: 62.60		FYN_HUMAN (1941-2216): 4.36e-59: 216: 43.12
+	Hs
		522818 HSP74_HUMAN (1-839): 0: 931: 62.60		SRC_HUMAN (1941-2216): 1.14e-58: 214: 43.12
+	Hs
		412286 HS105_HUMAN (1-839): 0: 925: 58.24		FYN_HUMAN (1941-2216): 4.36e-59: 216: 43.12
+	Hs
		523090 HS105_HUMAN (1-839): 0: 925: 58.24		SRC_HUMAN (1941-2216): 1.14e-58: 214: 43.12
+	Hs
		503499 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		EPHB2_HUMAN (1381-2344): 0: 601: 18.74
+	Hs
		435511 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25
+	Hs
		503438 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		FGFR3_HUMAN (1886-2215): 4.22e-59: 222: 38.73
+	Hs
		411965 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		FYN_HUMAN (1941-2216): 4.36e-59: 216: 43.12
+	Hs
		503340 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		SRC_HUMAN (1941-2216): 1.14e-58: 214: 43.12