HitPredict

Interactor 1: AP2A1 (O95782)
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
Gene: AP2A1

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	28190767, 38803224
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030666 - endocytic vesicle membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 977 Hs			1 685
+	Hs
		302094 AP2A2_HUMAN (1-977): 0: 832: 76.97		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475594 AP2B1_HUMAN (34-972): 0: 676: 17.11		UBC_HUMAN (1-685): 0: 846: 100.00
+	Zm
		111864 K7VAA4_MAIZE (3-856): 0: 602: 24.35		Q42415_MAIZE (229-685): 0: 548: 95.84
+	Mm
		476683 AP2A1_MOUSE (1-977): 0: 893: 97.75		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		321462 AP2A1_HUMAN (1-977): 0: 904: 100.00		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	At
		1091811 AP2A2_ARATH (8-977): 0: 731: 36.66		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Zm
		111863 K7VAA4_MAIZE (3-856): 0: 602: 24.35		Q41754_MAIZE (381-685): 3.03e-124: 375: 95.74
+	Rn
		1144175 Q66HM2_RAT (1-977): 0: 845: 79.39		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		476684 AP2A2_MOUSE (1-977): 0: 841: 79.29		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		302089 AP2A2_HUMAN (1-977): 0: 832: 76.97		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	At
		286688 APBLC_ARATH (34-973): 0: 624: 16.21		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1092397 APBLB_ARATH (34-973): 0: 613: 16.32		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1091731 AP1G1_ARATH (1-853): 0: 579: 24.08		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1092398 COPB1_ARATH (38-966): 0: 552: 11.80		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1013363 COPG_ARATH (23-974): 9.72e-180: 546: 14.48		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Mm
		477012 AP2B1_MOUSE (34-972): 0: 676: 17.01		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Rn
		923858 AP2B1_RAT (34-972): 0: 676: 17.11		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	At
		1091782 AP4E_ARATH (11-739): 1.25e-169: 521: 21.90		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Hs
		397894 AP2B1_HUMAN (34-972): 0: 676: 17.11		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69