HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0030335 - positive regulation of cell migration GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 1052
+	Hs
		324804 M4K4_HUMAN (1-1239): 0: 1227: 100.00		FAK2_HUMAN (35-1043): 0: 852: 44.78
+	Hs
		324761 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA5_HUMAN (208-760): 5.09e-123: 403: 26.17
+	Hs
		324809 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA7_HUMAN (388-756): 5.73e-121: 397: 32.53
+	Hs
		324742 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHB2_HUMAN (383-823): 1.06e-119: 395: 28.70
+	Hs
		201156 M4K4_HUMAN (1-1239): 0: 1227: 100.00		M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16
+	Hs
		324762 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA4_HUMAN (372-763): 1.33e-119: 393: 31.90
+	Hs
		324728 M4K4_HUMAN (1-1239): 0: 1227: 100.00		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Hs
		324717 M4K4_HUMAN (1-1239): 0: 1227: 100.00		LCK_HUMAN (412-691): 7.42e-111: 355: 37.37
+	Hs
		872460 MINK1_HUMAN (1-1239): 0: 1120: 59.29		EPHA5_HUMAN (208-760): 5.09e-123: 403: 26.17
+	Hs
		1072547 MINK1_HUMAN (1-1239): 0: 1120: 59.29		EPHA7_HUMAN (388-756): 5.73e-121: 397: 32.53
+	Hs
		872502 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHA5_HUMAN (208-760): 5.09e-123: 403: 26.17
+	Hs
		1072625 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHA7_HUMAN (388-756): 5.73e-121: 397: 32.53
+	Hs
		665680 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHB2_HUMAN (383-823): 1.06e-119: 395: 28.70
+	Hs
		201458 TNIK_HUMAN (1-1239): 0: 1101: 60.56		M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16
+	Hs
		508100 MINK1_HUMAN (1-1239): 0: 1120: 59.29		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Hs
		375068 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88
+	Hs
		411790 MINK1_HUMAN (1-1239): 0: 1120: 59.29		LCK_HUMAN (412-691): 7.42e-111: 355: 37.37
+	Hs
		508260 TNIK_HUMAN (1-1239): 0: 1101: 60.56		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Hs
		324738 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA1_HUMAN (428-680): 4.6e-63: 234: 45.88
+	Hs
		201476 SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13		M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16