Protein: CDK18
Cyclin-dependent kinase 18 (EC 2.7.11.22) (Cell division protein kinase 18) (PCTAIRE-motif protein kinase 3) (Serine/threonine-protein kinase PCTAIRE-3)

Gene: CDK18
Organism: Homo sapiens
Interactions: 141
UniProt ID: Q07002

Gene Ontology (top 5):
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

461395

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.886

High

296985

CCNK
Cyclin-K

3

20

High-throughput

0.861

High

1025537

CDK16
Cyclin-dependent kinase 16

3

16

High-throughput

0.847

High

1057604

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

3

10

High-throughput

0.847

High

1057612

DUS7
Dual specificity protein phosphatase 7

3

6

High-throughput

0.847

High

1057647

CDK15
Cyclin-dependent kinase 15

3

15

High-throughput

0.847

High

468295

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.827

High

543190

UBL4A
Ubiquitin-like protein 4A

2

11

High-throughput

0.811

High

856656

BAG6
Large proline-rich protein BAG6

2

10

High-throughput

0.811

High

51410

FSD2
Fibronectin type III and SPRY domain-containing protein 2

2

13

High-throughput

0.783

High

718885

CCND3
G1/S-specific cyclin-D3

2

20

High-throughput

0.783

High

1057602

LIPA1
Liprin-alpha-1

2

12

High-throughput

0.783

High

1057625

ZN774
Zinc finger protein 774

2

1

High-throughput

0.783

High

1057653

ZN426
Zinc finger protein 426

2

3

High-throughput

0.783

High

1057666

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

16

High-throughput

0.783

High

486688

FGR
Tyrosine-protein kinase Fgr

2

14

High-throughput

0.754

High

729770

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.720

High

690934

1433T
14-3-3 protein theta

5

20

Small-scale

0.714

High

990135

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.699

High

141833

ACKR2
Atypical chemokine receptor 2

2

2

High-throughput

0.694

High

443330

CDK1
Cyclin-dependent kinase 1

1

17

High-throughput

0.691

High

808032

CDN1A
Cyclin-dependent kinase inhibitor 1

1

20

High-throughput

0.691

High

1025452

CDK5
Cyclin-dependent kinase 5

1

17

High-throughput

0.691

High

1025617

CDK17
Cyclin-dependent kinase 17

1

16

High-throughput

0.691

High

1057643

GWL
Serine/threonine-protein kinase greatwall

1

13

High-throughput

0.691

High

1057656

RBM4
RNA-binding protein 4

1

8

High-throughput

0.691

High

1057668

RALY
RNA-binding protein Raly

1

3

High-throughput

0.691

High

1057618

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

17

High-throughput

0.675

High

966229

1433G
14-3-3 protein gamma

3

20

High-throughput

0.675

High

971434

1433E
14-3-3 protein epsilon

3

9

High-throughput

0.671

High

1057621

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

2

High-throughput

0.665

High

1057669

IKZF3
Zinc finger protein Aiolos

1

1

High-throughput

0.665

High

1049223

1433F
14-3-3 protein eta

3

20

High-throughput

0.662

High

316820

MTA2
Metastasis-associated protein MTA2

3

3

High-throughput

0.656

High

1057633

TTC29
Tetratricopeptide repeat protein 29

3

2

High-throughput

0.656

High

1057646

SFXN2
Sideroflexin-2

3

2

High-throughput

0.650

High

1057619

DNLZ
DNL-type zinc finger protein

3

0

High-throughput

0.628

High

539797

RALA
Ras-related protein Ral-A

1

15

High-throughput

0.618

High

605651

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

9

High-throughput

0.618

High

1057606

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

High-throughput

0.618

High

1057611

CDC37
Hsp90 co-chaperone Cdc37

1

7

High-throughput

0.618

High

1057615

LARP7
La-related protein 7

1

20

High-throughput

0.618

High

1057626

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

1057597

GOGA2
Golgin subfamily A member 2

3

18

High-throughput

0.616

High

1057608

K1H1
Keratin, type I cuticular Ha1

3

6

High-throughput

0.616

High

64531

CC88B
Coiled-coil domain-containing protein 88B

2

16

High-throughput

0.606

High

124595

EYA2
Protein phosphatase EYA2

2

2

High-throughput

0.606

High

476302

K1C16
Keratin, type I cytoskeletal 16

2

5

High-throughput

0.606

High

618024

K1C15
Keratin, type I cytoskeletal 15

2

5

High-throughput

0.606

High

928172

HAP1
Huntingtin-associated protein 1

2

13

High-throughput

0.606

High

1048830

REL
Proto-oncogene c-Rel

2

6

High-throughput

0.606

High

1057598

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

1057600

TRAF2
TNF receptor-associated factor 2

2

6

High-throughput

0.606

High

1057601

TRAF1
TNF receptor-associated factor 1

2

1

High-throughput

0.606

High

1057624

HMBX1
Homeobox-containing protein 1

2

10

High-throughput

0.606

High

1057628

ZN438
Zinc finger protein 438

2

3

High-throughput

0.606

High

1057629

TRI50
E3 ubiquitin-protein ligase TRIM50

2

7

High-throughput

0.606

High

1057642

HOOK2
Protein Hook homolog 2

2

18

High-throughput

0.606

High

1057645

KAD8
Adenylate kinase 8

2

2

High-throughput

0.606

High

1057663

HOME3
Homer protein homolog 3

2

3

High-throughput

0.606

High

1057664

ZRAN1
Ubiquitin thioesterase ZRANB1

2

3

High-throughput

0.606

High

1057674

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

2

18

High-throughput

0.606

High

899853

FXR1
RNA-binding protein FXR1

2

0

High-throughput

0.594

High

1057631

CC125
Coiled-coil domain-containing protein 125

2

0

High-throughput

0.580

High

1057660

GO45
Golgin-45

2

0

High-throughput

0.580

High

1057667

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

0

High-throughput

0.580

High

1057617

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.575

High

571941

TRI27
Zinc finger protein RFP

1

7

High-throughput

0.573

High

1057622

C102B
Coiled-coil domain-containing protein 102B

1

14

High-throughput

0.573

High

1057636

PNMA1
Paraneoplastic antigen Ma1

1

2

High-throughput

0.573

High

1057654

KIFC3
Kinesin-like protein KIFC3

1

3

High-throughput

0.573

High

1057657

TRI54
Tripartite motif-containing protein 54

1

17

High-throughput

0.573

High

1057658

TSG10
Testis-specific gene 10 protein

1

19

High-throughput

0.573

High

65034

GG6L9
Golgin subfamily A member 6-like protein 9

2

11

High-throughput

0.553

High

227213

KRT86
Keratin, type II cuticular Hb6

2

1

High-throughput

0.553

High

300341

KRT34
Keratin, type I cuticular Ha4

2

6

High-throughput

0.553

High

341759

K2C75
Keratin, type II cytoskeletal 75

2

1

High-throughput

0.553

High

1057607

RABE1
Rab GTPase-binding effector protein 1

2

13

High-throughput

0.553

High

1057632

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

1

High-throughput

0.553

High

1057634

CBY2
Protein chibby homolog 2

2

1

High-throughput

0.553

High

1057661

GORS2
Golgi reassembly-stacking protein 2

2

4

High-throughput

0.553

High

332503

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.549

High

1057638

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.549

High

407614

S100B
Protein S100-B

1

11

High-throughput

0.536

High

565879

EF2
Elongation factor 2

1

8

High-throughput

0.536

High

610631

TCPA
T-complex protein 1 subunit alpha

1

16

High-throughput

0.536

High

821318

TCPZ
T-complex protein 1 subunit zeta

1

15

High-throughput

0.536

High

842201

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

High-throughput

0.536

High

875927

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

881887

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

899004

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

899357

TCPD
T-complex protein 1 subunit delta

1

16

High-throughput

0.536

High

916647

PPP5
Serine/threonine-protein phosphatase 5

1

14

High-throughput

0.536

High

961706

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.536

High

977469

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

10

High-throughput

0.536

High

1006987

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.536

High

1057613

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

6

High-throughput

0.536

High

1057644

FUBP3
Far upstream element-binding protein 3

1

10

High-throughput

0.536

High

1057650

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

1057659

NSRP1
Nuclear speckle splicing regulatory protein 1

1

3

High-throughput

0.536

High

1057662

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

5

High-throughput

0.536

High

1057665

TRPS1
Zinc finger transcription factor Trps1

1

6

High-throughput

0.536

High

1057670

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

High-throughput

0.536

High

1057671

MAGD2
Melanoma-associated antigen D2

1

1

High-throughput

0.536

High

1057623

K1C40
Keratin, type I cytoskeletal 40

1

6

High-throughput

0.523

High

1057651

LZTS2
Leucine zipper putative tumor suppressor 2

1

18

High-throughput

0.523

High

1057610

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

1057614

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.513

High

421983

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

1033350

CDR2
Cerebellar degeneration-related protein 2

1

0

High-throughput

0.493

High

384142

CO1A1
Collagen alpha-1(I) chain

1

1

High-throughput

0.489

High

465958

CO1A2
Collagen alpha-2(I) chain

1

1

High-throughput

0.489

High

608256

EGLN
Endoglin

1

1

High-throughput

0.489

High

1057603

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

5

High-throughput

0.489

High

1057640

LAR4B
La-related protein 4B

1

12

High-throughput

0.489

High

1057673

CHTOP
Chromatin target of PRMT1 protein

1

1

High-throughput

0.489

High

1057639

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

324814

HEXI1
Protein HEXIM1

1

8

High-throughput

0.479

High

714060

PML
Protein PML

1

12

High-throughput

0.479

High

730533

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

1045209

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

1057605

ATR
Serine/threonine-protein kinase ATR

1

2

Small-scale

0.479

High

1057635

SERB1
SERPINE1 mRNA-binding protein 1

1

10

High-throughput

0.479

High

1057641

REQU
Zinc finger protein ubi-d4

1

2

High-throughput

0.479

High

1057648

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.479

High

1057672

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

319210

FCSD2
F-BAR and double SH3 domains protein 2

1

2

High-throughput

0.470

High

1057616

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

1057630

NUTM1
NUT family member 1

1

0

High-throughput

0.460

High

298594

RAD17
Cell cycle checkpoint protein RAD17

1

0

Small-scale

0.458

High

1057627

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

1057655

KATL1
Katanin p60 ATPase-containing subunit A-like 1

1

12

High-throughput

0.445

High

460807

CATB
Cathepsin B

1

1

High-throughput

0.437

High

1057652

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.426

High

319096

SC24D
Protein transport protein Sec24D

1

7

Small-scale

0.417

High

1057609

SC23A
Protein transport protein Sec23A

1

5

Small-scale

0.417

High

652631

CAH4
Carbonic anhydrase 4

2

0

High-throughput

0.318

High

1057620

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1057637

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.316

High

1057599

FP100
Fanconi anemia core complex-associated protein 100

1

0

High-throughput

0.279

Low

1057649

METH
Methionine synthase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025