HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: KIBRA (Q8IX03)
Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1)
Gene: WWC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	25023289, 24682284, 33961781, 21233212, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 1113
+	Hs
		325775 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWC2_HUMAN (5-1113): 0: 779: 48.44
+	Hs
		325937 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWC3_HUMAN (3-1113): 0: 742: 41.22
+	Hs
		1220087 LATS2_HUMAN (13-1121): 0: 751: 49.61		KIBRA_HUMAN (1-1113): 0: 842: 100.00
+	Hs
		1149656 LATS2_HUMAN (13-1121): 0: 751: 49.61		WWC2_HUMAN (5-1113): 0: 779: 48.44
+	Hs
		1344970 LATS2_HUMAN (13-1121): 0: 751: 49.61		WWC3_HUMAN (3-1113): 0: 742: 41.22
+	Hs
		325853 LATS1_HUMAN (1-1130): 0: 934: 100.00		ITCH_HUMAN (2-164): 5.57e-30: 130: 22.94
+	Hs
		325914 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWOX_HUMAN (5-113): 1.68e-31: 130: 29.46
+	Hs
		325886 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWP1_HUMAN (2-162): 9.09e-26: 117: 25.77
+	Hs
		325898 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF1_HUMAN (674-1092): 5.34e-17: 88.3: 12.33
+	Hs
		325859 LATS1_HUMAN (1-1130): 0: 934: 100.00		MAGI1_HUMAN (36-163): 3.73e-13: 76.5: 25.95
+	Hs
		325894 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF2_HUMAN (674-1078): 4.73e-13: 75.5: 10.24
+	Hs
		325772 LATS1_HUMAN (1-1130): 0: 934: 100.00		MAGI3_HUMAN (29-170): 2.34e-11: 70.7: 26.53
+	Hs
		125071 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWP2_HUMAN (35-303): 1.01e-10: 68.2: 16.36
+	Hs
		325656 LATS1_HUMAN (1-1130): 0: 934: 100.00		YAP1_HUMAN (37-159): 1.07e-10: 67.6: 19.84
+	Hs
		325655 LATS1_HUMAN (1-1130): 0: 934: 100.00		NEDD4_HUMAN (26-161): 2.24e-09: 64: 21.32
+	Hs
		1300675 LATS2_HUMAN (13-1121): 0: 751: 49.61		MAGI1_HUMAN (36-163): 3.73e-13: 76.5: 25.95
+	Hs
		808960 LATS2_HUMAN (13-1121): 0: 751: 49.61		YAP1_HUMAN (37-159): 1.07e-10: 67.6: 19.84
+	Hs
		808286 LATS2_HUMAN (13-1121): 0: 751: 49.61		NEDD4_HUMAN (26-161): 2.24e-09: 64: 21.32
+	Mm
		809076 LATS2_MOUSE (13-1102): 0: 734: 49.82		YAP1_MOUSE (1-56): 2.33e-11: 69.5: 41.67
+	Hs
		1336122 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		SMUF1_HUMAN (674-1092): 5.34e-17: 88.3: 12.33