HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	29787761, 38280479, 20412773, 26116754, 27847303, 21555462, 22078877
Identification Methods	pull down, proximity labelling technology, enzymatic study, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0035329 - hippo signaling GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 400
+	Mm
		1207482 LATS1_MOUSE (1-1130): 0: 922: 93.10		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		325656 LATS1_HUMAN (1-1130): 0: 934: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		325886 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWP1_HUMAN (3-386): 5.05e-64: 222: 13.86
+	Hs
		325853 LATS1_HUMAN (1-1130): 0: 934: 100.00		ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83
+	Hs
		125071 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		325898 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62
+	Hs
		325797 LATS1_HUMAN (1-1130): 0: 934: 100.00		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		325888 LATS1_HUMAN (1-1130): 0: 934: 100.00		SAV1_HUMAN (2-252): 3.57e-48: 169: 15.89
+	Hs
		325775 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWC2_HUMAN (121-264): 2.83e-43: 163: 15.97
+	Hs
		325772 LATS1_HUMAN (1-1130): 0: 934: 100.00		MAGI3_HUMAN (3-246): 4.83e-43: 162: 19.28
+	Hs
		325937 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWC3_HUMAN (119-258): 4.68e-41: 156: 18.57
+	Hs
		325859 LATS1_HUMAN (1-1130): 0: 934: 100.00		MAGI1_HUMAN (10-212): 9.04e-40: 153: 15.74
+	Hs
		808960 LATS2_HUMAN (13-1121): 0: 751: 49.61		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		325894 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF2_HUMAN (156-326): 4.16e-25: 109: 11.92
+	Hs
		325655 LATS1_HUMAN (1-1130): 0: 934: 100.00		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		325914 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09
+	Hs
		1220087 LATS2_HUMAN (13-1121): 0: 751: 49.61		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		1149656 LATS2_HUMAN (13-1121): 0: 751: 49.61		WWC2_HUMAN (121-264): 2.83e-43: 163: 15.97
+	Hs
		1300675 LATS2_HUMAN (13-1121): 0: 751: 49.61		MAGI1_HUMAN (10-212): 9.04e-40: 153: 15.74
+	Hs
		808286 LATS2_HUMAN (13-1121): 0: 751: 49.61		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00