Protein: MK04
Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK)

Gene: MK04, MAPK4
Organism: Homo sapiens
Interactions: 68
UniProt ID: P31152

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678567

MAPK5
MAP kinase-activated protein kinase 5

4

20

Small-scale

0.905

High

437925

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.802

High

431569

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

678536

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.756

High

176391

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

4

High-throughput

0.691

High

270377

KS6A5
Ribosomal protein S6 kinase alpha-5

1

20

High-throughput

0.691

High

272851

KS6A4
Ribosomal protein S6 kinase alpha-4

1

20

High-throughput

0.691

High

312779

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

20

High-throughput

0.691

High

678545

IRAK1
Interleukin-1 receptor-associated kinase 1

1

14

High-throughput

0.691

High

678547

RD23B
UV excision repair protein RAD23 homolog B

1

9

High-throughput

0.691

High

678552

PAK1
Serine/threonine-protein kinase PAK 1

1

8

High-throughput

0.691

High

678553

PAK2
Serine/threonine-protein kinase PAK 2

1

7

High-throughput

0.691

High

678554

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

16

High-throughput

0.691

High

678555

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

14

High-throughput

0.691

High

678556

CDC37
Hsp90 co-chaperone Cdc37

1

8

High-throughput

0.691

High

678557

MK06
Mitogen-activated protein kinase 6

1

17

High-throughput

0.691

High

678573

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

19

High-throughput

0.691

High

678578

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

High-throughput

0.691

High

216456

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

3

High-throughput

0.628

High

678550

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

2

12

High-throughput

0.628

High

678566

RB6I2
ELKS/Rab6-interacting/CAST family member 1

2

14

High-throughput

0.628

High

678574

SAHH3
Adenosylhomocysteinase 3

2

3

High-throughput

0.628

High

648464

CALL3
Calmodulin-like protein 3

1

11

High-throughput

0.625

High

678568

DJC10
DnaJ homolog subfamily C member 10

1

7

High-throughput

0.618

High

678569

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

13

High-throughput

0.618

High

678551

DUS2
Dual specificity protein phosphatase 2

1

20

High-throughput

0.618

High

678564

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

3

1

High-throughput

0.616

High

678581

TECR
Very-long-chain enoyl-CoA reductase

2

0

High-throughput

0.602

High

678565

PKHH3
Pleckstrin homology domain-containing family H member 3

2

3

High-throughput

0.574

High

678539

CRK
Adapter molecule crk

1

4

High-throughput

0.541

High

156235

PSA7
Proteasome subunit alpha type-7

1

5

High-throughput

0.536

High

393062

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

7

High-throughput

0.536

High

503523

HSP7C
Heat shock cognate 71 kDa protein

1

12

High-throughput

0.536

High

573140

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.536

High

676819

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

4

High-throughput

0.536

High

678538

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.536

High

678540

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

678541

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

678542

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

678543

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

678544

SMCA2
Probable global transcription activator SNF2L2

1

3

High-throughput

0.536

High

678546

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

4

High-throughput

0.536

High

678549

PRKDC
DNA-dependent protein kinase catalytic subunit

1

2

High-throughput

0.536

High

678559

HKDC1
Hexokinase HKDC1

1

2

High-throughput

0.536

High

678560

ATD3B
ATPase family AAA domain-containing protein 3B

1

13

High-throughput

0.536

High

678561

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

10

High-throughput

0.536

High

678563

SFXN4
Sideroflexin-4

1

2

High-throughput

0.536

High

678572

GCN1
Stalled ribosome sensor GCN1

1

11

High-throughput

0.536

High

678577

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.536

High

678579

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

678580

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.536

High

678583

DIC
Mitochondrial dicarboxylate carrier

1

11

High-throughput

0.536

High

678585

CHIP
E3 ubiquitin-protein ligase CHIP

1

11

High-throughput

0.536

High

153218

ACOT8
Acyl-coenzyme A thioesterase 8

1

0

High-throughput

0.513

High

678558

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.513

High

678562

ASTL
Astacin-like metalloendopeptidase

1

0

High-throughput

0.513

High

50097

HACL2
2-hydroxyacyl-CoA lyase 2

1

4

High-throughput

0.489

High

678571

FACR1
Fatty acyl-CoA reductase 1

1

1

High-throughput

0.489

High

678582

HPBP1
Hsp70-binding protein 1

1

3

High-throughput

0.489

High

678586

XCT
Cystine/glutamate transporter

1

2

High-throughput

0.489

High

316584

ACSL3
Fatty acid CoA ligase Acsl3

1

3

High-throughput

0.479

High

678537

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

678548

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.479

High

678584

FZR1
Fizzy-related protein homolog

1

9

High-throughput

0.479

High

678575

SFXN2
Sideroflexin-2

1

2

High-throughput

0.437

High

532901

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.279

Low

678570

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

678576

PIGS
GPI transamidase component PIG-S

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024