HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

Property	Details
Experiments	15778465, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 248
+	Hs
		330944 PAK4_HUMAN (1-591): 0: 586: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		330968 PAK4_HUMAN (1-591): 0: 586: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		684345 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		910063 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		330862 PAK4_HUMAN (1-591): 0: 586: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		330872 PAK4_HUMAN (1-591): 0: 586: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		330938 PAK4_HUMAN (1-591): 0: 586: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		927566 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		330987 PAK4_HUMAN (1-591): 0: 586: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		684207 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		909811 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Mm
		910275 DCLK2_MOUSE (31-591): 2.24e-132: 406: 17.13		1433E_MOUSE (2-246): 4.41e-146: 410: 60.41
+	Hs
		647307 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683743 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		905151 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		982533 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		647105 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683540 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		904852 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		982272 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20