Protein: SOX5
Transcription factor SOX-5

Gene: SOX5
Organism: Homo sapiens
Interactions: 167
UniProt ID: P35711

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001502 - cartilage condensation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

776152

SOX13
Transcription factor SOX-13

3

17

High-throughput

0.861

High

141197

SOX1
Transcription factor SOX-1

2

19

High-throughput

0.811

High

776030

SOX6
Transcription factor SOX-6

2

17

High-throughput

0.811

High

776031

SOX11
Transcription factor SOX-11

2

16

High-throughput

0.811

High

209958

CRX
Cone-rod homeobox protein

5

20

High-throughput

0.717

High

776059

TLE5
TLE family member 5

4

20

High-throughput

0.699

High

776029

SOX5
Transcription factor SOX-5

1

16

High-throughput

0.698

High

776052

TFAM
Transcription factor A, mitochondrial

1

17

High-throughput

0.691

High

473824

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.634

High

682010

RBTN1
Rhombotin-1

2

20

High-throughput

0.633

High

776056

ARI5A
AT-rich interactive domain-containing protein 5A

2

20

High-throughput

0.633

High

776099

FOXP4
Forkhead box protein P4

2

20

Small-scale

0.624

High

776128

FOXP1
Forkhead box protein P1

2

20

Small-scale

0.624

High

576178

PO2F1
POU domain, class 2, transcription factor 1

1

20

High-throughput

0.618

High

776034

SOX2
Transcription factor SOX-2

1

16

High-throughput

0.618

High

776113

CIC
Protein capicua homolog

1

16

High-throughput

0.618

High

776120

SOX7
Transcription factor SOX-7

1

16

High-throughput

0.618

High

776133

HM20A
High mobility group protein 20A

1

20

High-throughput

0.618

High

776138

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

20

High-throughput

0.618

High

776122

KIFC3
Kinesin-like protein KIFC3

3

4

High-throughput

0.616

High

776087

CEP85
Centrosomal protein of 85 kDa

3

11

High-throughput

0.609

High

297764

PIAS2
E3 SUMO-protein ligase PIAS2

2

11

High-throughput

0.606

High

772101

MSX2
Homeobox protein MSX-2

2

20

High-throughput

0.606

High

776047

RNF4
E3 ubiquitin-protein ligase RNF4

2

3

High-throughput

0.606

High

776108

BIRC7
Baculoviral IAP repeat-containing protein 7

2

3

High-throughput

0.606

High

776132

ZBT26
Zinc finger and BTB domain-containing protein 26

2

20

High-throughput

0.606

High

776154

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

2

High-throughput

0.606

High

776156

MAGD1
Melanoma-associated antigen D1

2

7

High-throughput

0.606

High

776060

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.601

High

776070

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.595

High

776040

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.584

High

681762

RBTN2
Rhombotin-2

1

20

High-throughput

0.573

High

776088

MORN3
MORN repeat-containing protein 3

1

4

High-throughput

0.573

High

776106

KAT5
Histone acetyltransferase KAT5

1

3

High-throughput

0.573

High

776131

CBX8
Chromobox protein homolog 8

1

13

High-throughput

0.573

High

776137

ZN581
Zinc finger protein 581

1

11

High-throughput

0.573

High

190048

FOXP2
Forkhead box protein P2

1

20

Small-scale

0.561

High

776063

TRAF2
TNF receptor-associated factor 2

2

15

High-throughput

0.553

High

776053

CDK6
Cyclin-dependent kinase 6

1

9

Small-scale

0.550

High

776107

TET5B
Terminal nucleotidyltransferase 5B

1

0

High-throughput

0.549

High

586546

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.541

High

776037

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

582075

PGAM2
Phosphoglycerate mutase 2

1

2

High-throughput

0.536

High

601930

ZNF7
Zinc finger protein 7

1

2

High-throughput

0.536

High

776058

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

5

High-throughput

0.536

High

776149

RCOR1
REST corepressor 1

1

20

High-throughput

0.536

High

776148

CDC23
Cell division cycle protein 23 homolog

1

7

High-throughput

0.523

High

391576

FRIH
Ferritin heavy chain

1

0

High-throughput

0.518

High

719111

MPIP1
M-phase inducer phosphatase 1

1

0

High-throughput

0.518

High

776086

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.518

High

142870

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.515

High

107794

SUMO5
Small ubiquitin-related modifier 5

1

9

High-throughput

0.515

High

776091

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.513

High

177656

SMAD7
Mothers against decapentaplegic homolog 7

1

20

High-throughput

0.508

High

776072

SMAD1
Mothers against decapentaplegic homolog 1

1

20

High-throughput

0.508

High

776117

SMAD5
Mothers against decapentaplegic homolog 5

1

20

High-throughput

0.508

High

184761

SHOX
Short stature homeobox protein

1

20

Small-scale

0.506

High

775801

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.501

High

776042

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.500

High

776055

EWS
RNA-binding protein EWS

1

18

High-throughput

0.500

High

776062

ILF2
Interleukin enhancer-binding factor 2

1

7

High-throughput

0.500

High

776065

G3BP1
Ras GTPase-activating protein-binding protein 1

1

8

High-throughput

0.500

High

776095

PABP2
Polyadenylate-binding protein 2

1

12

High-throughput

0.500

High

776101

CCAR2
Cell cycle and apoptosis regulator protein 2

1

6

High-throughput

0.500

High

776109

RBM33
RNA-binding protein 33

1

20

High-throughput

0.500

High

776116

PHB2
Prohibitin-2

1

3

High-throughput

0.500

High

776124

PDIP3
Polymerase delta-interacting protein 3

1

6

High-throughput

0.500

High

776125

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.500

High

776136

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

14

High-throughput

0.500

High

776115

TTC1
Tetratricopeptide repeat protein 1

1

4

High-throughput

0.494

High

161593

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

7

High-throughput

0.489

High

706079

S10A2
Protein S100-A2

1

7

High-throughput

0.489

High

776129

CPVL
Probable serine carboxypeptidase CPVL

1

2

High-throughput

0.489

High

776140

KLHL9
Kelch-like protein 9

1

7

High-throughput

0.489

High

776045

UBC9
SUMO-conjugating enzyme UBC9

1

10

High-throughput

0.481

High

161423

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174318

ZN609
Zinc finger protein 609

1

19

High-throughput

0.479

High

180728

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

261375

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

20

High-throughput

0.479

High

278255

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

339672

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

505527

ATX1L
Ataxin-1-like

1

16

High-throughput

0.479

High

538372

EGR2
E3 SUMO-protein ligase EGR2

1

20

High-throughput

0.479

High

612899

EGR1
Early growth response protein 1

1

18

Small-scale

0.479

High

685116

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

776032

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.479

High

776036

TAF6
Transcription initiation factor TFIID subunit 6

1

1

Small-scale

0.479

High

776039

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.479

High

776049

FOXK1
Forkhead box protein K1

1

20

High-throughput

0.479

High

776054

SATB1
DNA-binding protein SATB1

1

11

High-throughput

0.479

High

776057

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

776061

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

776064

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

776066

PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2

1

2

High-throughput

0.479

High

776071

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

776074

ZFHX3
Zinc finger homeobox protein 3

1

18

High-throughput

0.479

High

776076

TBR1
T-box brain protein 1

1

16

High-throughput

0.479

High

776078

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

776079

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

11

High-throughput

0.479

High

776080

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

8

High-throughput

0.479

High

776082

TSH3
Teashirt homolog 3

1

17

High-throughput

0.479

High

776084

LIN54
Protein lin-54 homolog

1

2

High-throughput

0.479

High

776089

MCAF1
Activating transcription factor 7-interacting protein 1

1

20

High-throughput

0.479

High

776090

BCOR
BCL-6 corepressor

1

18

High-throughput

0.479

High

776093

POGZ
Pogo transposable element with ZNF domain

1

5

High-throughput

0.479

High

776096

ZFHX4
Zinc finger homeobox protein 4

1

17

High-throughput

0.479

High

776098

P66A
Transcriptional repressor p66-alpha

1

12

High-throughput

0.479

High

776103

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

776104

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

20

High-throughput

0.479

High

776105

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

776110

ZN503
Zinc finger protein 503

1

3

High-throughput

0.479

High

776111

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

8

High-throughput

0.479

High

776112

ZN521
Zinc finger protein 521

1

3

High-throughput

0.479

High

776114

FEV
Protein FEV

1

20

High-throughput

0.479

High

776119

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

776121

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.479

High

776123

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.479

High

776126

SP130
Histone deacetylase complex subunit SAP130

1

18

High-throughput

0.479

High

776127

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

1

20

High-throughput

0.479

High

776130

ZHX3
Zinc fingers and homeoboxes protein 3

1

20

High-throughput

0.479

High

776139

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

20

High-throughput

0.479

High

776142

RCOR3
REST corepressor 3

1

20

High-throughput

0.479

High

776143

MBD2
Methyl-CpG-binding domain protein 2

1

7

High-throughput

0.479

High

776144

LHX3
LIM/homeobox protein Lhx3

1

20

High-throughput

0.479

High

776145

TCF20
Transcription factor 20

1

20

High-throughput

0.479

High

776146

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.479

High

776147

DACH1
Dachshund homolog 1

1

3

High-throughput

0.479

High

776150

ZHX1
Zinc fingers and homeoboxes protein 1

1

20

High-throughput

0.479

High

776151

ZN608
Zinc finger protein 608

1

14

High-throughput

0.479

High

776153

SATB2
DNA-binding protein SATB2

1

11

High-throughput

0.479

High

776157

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

776158

ZHX2
Zinc fingers and homeoboxes protein 2

1

20

High-throughput

0.479

High

776050

PR20C
Proline-rich protein 20C

1

3

High-throughput

0.470

High

776092

Q7KZS0
SUMO-conjugating enzyme UBC9

1

10

High-throughput

0.470

High

776094

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

3

High-throughput

0.470

High

776073

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

0

High-throughput

0.458

High

421610

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.457

High

183597

RT12
Small ribosomal subunit protein uS12m

1

4

High-throughput

0.457

High

299088

FLOT1
Flotillin-1

1

8

High-throughput

0.457

High

475280

RS17
Small ribosomal subunit protein eS17

1

3

High-throughput

0.457

High

776035

PRC2A
Protein PRRC2A

1

20

High-throughput

0.457

High

776038

SEC13
Protein SEC13 homolog

1

16

High-throughput

0.457

High

776043

RS11
Small ribosomal subunit protein uS17

1

4

High-throughput

0.457

High

776048

RT34
Small ribosomal subunit protein mS34

1

3

High-throughput

0.457

High

776067

FLOT2
Flotillin-2

1

8

High-throughput

0.457

High

776068

CAPR1
Caprin-1

1

9

High-throughput

0.457

High

776075

DREB
Drebrin

1

4

High-throughput

0.457

High

776102

LS14A
Protein LSM14 homolog A

1

20

High-throughput

0.457

High

776134

ATD3A
ATPase family AAA domain-containing protein 3A

1

7

High-throughput

0.457

High

776141

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.457

High

776155

PRC2C
Protein PRRC2C

1

20

High-throughput

0.457

High

776051

PR20A
Proline-rich protein 20A

1

3

High-throughput

0.439

High

65706

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

4

High-throughput

0.437

High

776041

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.437

High

776044

RL39
Large ribosomal subunit protein eL39

1

3

High-throughput

0.437

High

776069

GSE1
Genetic suppressor element 1

1

4

High-throughput

0.437

High

776077

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

776081

ZMYM4
Zinc finger MYM-type protein 4

1

4

High-throughput

0.437

High

776097

PRSR1
Proline and serine-rich protein 1

1

20

High-throughput

0.437

High

776118

PYGO2
Pygopus homolog 2

1

2

High-throughput

0.437

High

776135

RBM28
RNA-binding protein 28

1

3

High-throughput

0.437

High

776083

ANR40
Ankyrin repeat domain-containing protein 40

2

0

High-throughput

0.328

High

776100

TEX11
Testis-expressed protein 11

2

0

High-throughput

0.316

High

776033

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.282

High

776046

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.261

Low

776085

MSD2
Myb/SANT-like DNA-binding domain-containing protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025