HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FHA~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0005912 - adherens junction GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 1824
+	Hs
		876512 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		331091 PAK4_HUMAN (1-591): 0: 586: 100.00		KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64
+	Mm
		1112939 PAK6_MOUSE (1-591): 4.83e-166: 490: 45.66		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		1027366 STK3_HUMAN (289-588): 1.76e-123: 374: 35.43		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		1023046 STK4_HUMAN (298-588): 1.44e-122: 372: 35.50		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		850715 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		1234199 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		NEB1_HUMAN (1002-1092): 1.04e-19: 98.7: 40.00
+	Hs
		1073484 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Mm
		1143553 KS6A2_MOUSE (318-583): 3.96e-113: 355: 25.26		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		942348 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51
+	Hs
		850651 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		682219 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		MYO5A_HUMAN (1369-1800): 2.36e-11: 71.5: 10.74
+	Hs
		1049960 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		1073494 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		NEB1_HUMAN (1002-1092): 1.04e-19: 98.7: 40.00
+	Hs
		883917 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		SYJ2B_HUMAN (1013-1098): 2.51e-20: 91: 32.96
+	Hs
		1066806 STK26_HUMAN (315-574): 2.21e-52: 186: 38.31		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		1020231 STK26_HUMAN (315-574): 2.21e-52: 186: 38.31		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		1026159 PAK1_HUMAN (3-210): 7.55e-29: 122: 19.62		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		1068687 PAK5_HUMAN (1-323): 8.93e-40: 156: 27.68		PLEC_HUMAN (1384-1680): 9.8e-11: 69.6: 16.67
+	Hs
		1026905 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85