HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31248990
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Chromo~PHD, PHD~PHD
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 1912
+	Hs
		203687 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		1059639 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		1059880 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		1059797 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Mm
		1125396 Q6AXH7_MOUSE (904-1188): 1.25e-58: 218: 22.48		Q5DTP7_MOUSE (1-1900): 0: 1691: 97.91
+	Hs
		975252 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		1018505 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		CHD3_HUMAN (23-1905): 0: 1595: 66.89
+	Hs
		229270 NSD2_HUMAN (1-1365): 0: 980: 100.00		SMCA5_HUMAN (578-1624): 0: 791: 26.01
+	Hs
		975235 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		CHD3_HUMAN (23-1905): 0: 1595: 66.89
+	Hs
		1317720 NSD3_HUMAN (116-1340): 0: 758: 45.19		CHD8_HUMAN (489-1678): 0: 752: 28.31
+	Dm
		332724 CHDM_DROME (1238-1285): 6.78e-12: 72.7: 42.00		CHDM_DROME (1-1904): 0: 1364: 50.85
+	Sp
		144529 CLR4_SCHPO (947-1202): 5.1e-59: 214: 23.10		HRP3_SCHPO (535-1673): 0: 816: 28.33
+	Hs
		1080420 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		CHD7_HUMAN (3-1678): 0: 805: 23.02
+	Hs
		229411 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		SMCA5_HUMAN (578-1624): 0: 791: 26.01
+	Hs
		1080145 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		CHD6_HUMAN (279-1685): 0: 782: 24.76
+	Hs
		658681 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		SMCA1_HUMAN (617-1597): 0: 779: 27.44
+	Hs
		1080369 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		CHD8_HUMAN (489-1678): 0: 752: 28.31
+	Hs
		151495 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		CHD2_HUMAN (493-1689): 0: 739: 30.57
+	Hs
		151417 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		CHD1_HUMAN (491-1733): 0: 734: 27.99
+	Hs
		151444 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		CHD1_HUMAN (491-1733): 0: 734: 27.99