Protein: DEN2B
DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein)

Gene: DEN2B, DENND2B
Organism: Homo sapiens
Interactions: 35
UniProt ID: P78524

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005886 - plasma membrane
GO:0005938 - cell cortex
GO:0055037 - recycling endosome
GO:0070374 - positive regulation of ERK1 and ERK2 cascade

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

966189

1433G
14-3-3 protein gamma

3

20

High-throughput

0.609

High

971398

1433E
14-3-3 protein epsilon

2

5

High-throughput

0.580

High

990089

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.558

High

1008069

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

730504

1433S
14-3-3 protein sigma

2

20

High-throughput

0.549

High

772737

MYH9
Myosin-9

1

1

High-throughput

0.536

High

1008074

L2GL2
LLGL scribble cell polarity complex component 2

1

3

High-throughput

0.536

High

1008081

ANLN
Anillin

1

4

High-throughput

0.536

High

362244

ABL1
Tyrosine-protein kinase ABL1

1

10

Small-scale

0.527

High

690898

1433T
14-3-3 protein theta

1

20

High-throughput

0.506

High

463056

YES
Tyrosine-protein kinase Yes

1

9

High-throughput

0.501

High

968252

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.489

High

1008078

MY18A
Unconventional myosin-XVIIIa

1

2

High-throughput

0.489

High

1008079

MYO19
Unconventional myosin-XIX

1

5

High-throughput

0.489

High

987537

GRB2
Growth factor receptor-bound protein 2

1

13

Small-scale

0.479

High

462348

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

High-throughput

0.470

High

301399

WFS1
Wolframin

1

1

High-throughput

0.470

High

1008072

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.464

High

440489

FYN
Tyrosine-protein kinase Fyn

1

9

High-throughput

0.445

High

956844

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.445

High

371736

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

729741

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.437

High

1008070

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.437

High

1008071

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.437

High

239037

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.407

High

765376

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.407

High

994982

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.407

High

1008076

RNF10
E3 ubiquitin-protein ligase RNF10

1

1

High-throughput

0.407

High

1008082

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.407

High

843481

HD
Huntingtin

1

0

High-throughput

0.268

Low

1008073

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low

1008075

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.232

Low

1008077

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.232

Low

1008080

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.232

Low

1008083

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025