HitPredict

Interactor 1: O96989 (O96989)
CDC45L (Cell division cycle 45) (EG:BACR7A4.11 protein) (LD35753p)
Gene: Cdc45

Interactor 2: MCM3 (Q9XYU1)
DNA replication licensing factor Mcm3 (EC 3.6.4.12) (Minichromosome maintenance 3 protein) (DmMCM3)
Gene: MCM3

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	21378962, 25117490, 16798881, 11024168, 20122406
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC45~MCM_lid, CDC45~MCM_N, CDC45~MCM_OB
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0071162 - CMG complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 575 Dm			1 819
+	Hs
		264171 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM3_HUMAN (5-819): 0: 880: 61.54
+	Hs
		264189 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM2_HUMAN (11-723): 0: 719: 31.95
+	Hs
		264177 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM5_HUMAN (2-702): 0: 699: 28.94
+	Hs
		264178 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM7_HUMAN (5-665): 0: 688: 32.79
+	Hs
		264202 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM6_HUMAN (6-756): 0: 678: 24.88
+	Dm
		332394 O96989_DROME (1-575): 0: 747: 100.00		MCM2_DROME (11-722): 0: 686: 30.19
+	Hs
		264176 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM4_HUMAN (6-657): 0: 642: 28.78
+	Dm
		332400 O96989_DROME (1-575): 0: 747: 100.00		MCM5_DROME (7-727): 0: 666: 29.70
+	Dm
		332397 O96989_DROME (1-575): 0: 747: 100.00		MCM6_DROME (2-783): 0: 662: 23.89
+	Dm
		332395 O96989_DROME (1-575): 0: 747: 100.00		MCM4_DROME (6-738): 0: 651: 26.21
+	Sp
		251151 CDC45_SCHPO (16-571): 0: 599: 27.48		MCM3_SCHPO (1-819): 0: 764: 44.86
+	Sp
		251152 CDC45_SCHPO (16-571): 0: 599: 27.48		MCM2_SCHPO (6-664): 0: 674: 32.14
+	Sc
		622198 CDC45_YEAST (17-572): 0: 563: 24.17		MCM3_YEAST (42-819): 0: 691: 41.22
+	Sc
		667640 CDC45_YEAST (17-572): 0: 563: 24.17		MCM2_YEAST (8-650): 0: 663: 31.76
+	Dm
		332410 O96989_DROME (1-575): 0: 747: 100.00		MCM7_DROME (97-646): 1.59e-86: 291: 37.43
+	Sp
		251147 CDC45_SCHPO (16-571): 0: 599: 27.48		MCM7_SCHPO (1-646): 2.45e-88: 297: 32.85
+	Sc
		667899 CDC45_YEAST (17-572): 0: 563: 24.17		MCM5_YEAST (111-644): 7.01e-91: 305: 35.36
+	Sc
		744795 CDC45_YEAST (17-572): 0: 563: 24.17		MCM7_YEAST (105-646): 4.01e-86: 293: 36.87