HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: TBA4A (P68366)
Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain)
Gene: TUBA4A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	23956138, 16799092, 24189400
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 448
+	Hs
		338607 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBA1A_HUMAN (1-439): 0: 712: 97.04
+	Hs
		337782 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBB5_HUMAN (1-439): 0: 697: 40.55
+	Hs
		338266 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBB4B_HUMAN (1-437): 0: 695: 40.28
+	Hs
		601883 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		TBA4A_HUMAN (1-448): 0: 724: 100.00
+	Hs
		601882 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		TBA1B_HUMAN (1-439): 0: 715: 97.49
+	Hs
		428019 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		TBB5_HUMAN (1-439): 0: 697: 40.55
+	Hs
		933452 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		TBA4A_HUMAN (1-448): 0: 724: 100.00
+	Hs
		665575 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		TBA1B_HUMAN (1-439): 0: 715: 97.49
+	Hs
		1072528 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		TBA1A_HUMAN (1-439): 0: 712: 97.04
+	Hs
		665203 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		TBA1B_HUMAN (1-439): 0: 715: 97.49
+	Hs
		428109 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB5_HUMAN (1-439): 0: 697: 40.55
+	Hs
		872631 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB4B_HUMAN (1-437): 0: 695: 40.28
+	Hs
		872702 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB2B_HUMAN (1-440): 0: 694: 39.77
+	Rn
		544865 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		TBA4A_RAT (1-448): 0: 724: 100.00
+	Hs
		428222 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		TBB5_HUMAN (1-439): 0: 697: 40.55
+	Hs
		411416 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		TBA1A_HUMAN (1-439): 0: 712: 97.04
+	Hs
		411272 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		TBB5_HUMAN (1-439): 0: 697: 40.55
+	Gg
		94426 KSYK_CHICK (718-961): 1.71e-55: 206: 41.30		TBA2_CHICK (1-446): 0: 783: 83.41
+	Hs
		983628 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		TBA1A_HUMAN (1-439): 0: 712: 97.04
+	Gg
		94429 KSYK_CHICK (718-961): 1.71e-55: 206: 41.30		TBB7_CHICK (1-439): 0: 697: 40.55