HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.897

Property	Details
Experiments	25402006, 24658140, 9506989, unassigned2173
Identification Methods	two hybrid, protein complementation assay, pull down, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0032991 - protein-containing complex GO:0042327 - positive regulation of phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 594
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (36-592): 1.11e-137: 423: 14.55
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (40-588): 1.7e-95: 313: 12.26
+	Hs
		145963 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH2B2_HUMAN (301-581): 7.5e-55: 198: 16.29
+	Hs
		338081 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TEC_HUMAN (293-590): 2.81e-52: 191: 12.33
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (443-590): 1.24e-46: 173: 22.08
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (443-590): 9.65e-47: 174: 22.08
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (441-593): 8.45e-46: 171: 18.63
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (438-594): 3.18e-45: 169: 20.38
+	Hs
		338144 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BLK_HUMAN (449-593): 3.44e-45: 169: 22.82
+	Hs
		338080 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MATK_HUMAN (454-587): 1.29e-36: 144: 26.81
+	Hs
		338069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (489-575): 3.64e-20: 91.4: 29.89
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		338093 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KSYK_HUMAN (459-593): 3.15e-16: 84.1: 27.94