Protein: SAR1
Small COPII coat GTPase SAR1 (EC 3.6.5.-) (GTP-binding protein SAR1) (Secretion-associated RAS-related protein 1)

Gene: SAR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 79
UniProt ID: P20606

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000266 - mitochondrial fission
GO:0003400 - regulation of COPII vesicle coating
GO:0003924 - GTPase activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

582410

SEC23
Protein transport protein SEC23

8

14

Small-scale

0.968

High

633554

SEC24
Protein transport protein SEC24

5

14

Small-scale

0.912

High

547902

SEC12
Guanine nucleotide-exchange factor SEC12

2

10

Small-scale

0.806

High

633530

BET1
Protein transport protein BET1

4

6

Small-scale

0.698

High

633546

NEL1
GTPase-activating protein NEL1

1

15

Small-scale

0.692

High

633533

SED4
Putative guanine nucleotide-exchange factor SED4

1

3

Small-scale

0.647

High

633547

SEC31
Protein transport protein SEC31

1

8

Small-scale

0.647

High

633538

EMP24
Endosomal protein P24B

2

14

Small-scale

0.646

High

633528

SEC22
Protein transport protein SEC22

2

11

Small-scale

0.621

High

633573

SEC13
Protein transport protein SEC13

1

8

High-throughput

0.618

High

633577

CORO
Coronin-like protein

1

5

High-throughput

0.595

High

578832

HSC82
ATP-dependent molecular chaperone HSC82

2

11

High-throughput

0.584

High

633557

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

7

High-throughput

0.584

High

633568

SED5
Integral membrane protein SED5

2

20

Small-scale

0.571

High

633534

BOS1
Protein transport protein BOS1

1

1

Small-scale

0.561

High

448252

HIP1
Histidine permease

1

12

Small-scale

0.554

High

633542

DOA1
Protein DOA1

1

4

Small-scale

0.553

High

633548

TEM1
Protein TEM1

1

20

High-throughput

0.536

High

633564

BRE5
UBP3-associated protein BRE5

1

6

High-throughput

0.536

High

633567

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

392214

HSP82
ATP-dependent molecular chaperone HSP82

2

11

High-throughput

0.533

High

633571

TVP15
Golgi apparatus membrane protein TVP15

1

2

High-throughput

0.508

High

633561

ERV14
ER-derived vesicles protein ERV14

1

1

Small-scale

0.501

High

440897

CDC7
Cell division control protein 7

1

11

High-throughput

0.489

High

633585

IES3
Ino eighty subunit 3

1

1

High-throughput

0.489

High

633559

SEC16
COPII coat assembly protein SEC16

1

0

Small-scale

0.480

High

618848

GAP1
General amino-acid permease GAP1

1

8

Small-scale

0.479

High

633529

VPS34
Phosphatidylinositol 3-kinase VPS34

1

12

High-throughput

0.479

High

633535

CDC48
Cell division control protein 48

1

11

High-throughput

0.479

High

633540

TOM20
Mitochondrial import receptor subunit TOM20

1

6

High-throughput

0.479

High

633544

ATG8
Autophagy-related protein 8

1

8

High-throughput

0.479

High

633545

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

633550

ERV46
ER-derived vesicles protein ERV46

1

7

Small-scale

0.479

High

633551

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

633562

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

633563

ERV29
ER-derived vesicles protein ERV29

1

1

Small-scale

0.479

High

633565

TMEDA
Endoplasmic reticulum vesicle protein 25

1

16

Small-scale

0.479

High

633566

NUM1
Nuclear migration protein NUM1

1

16

High-throughput

0.479

High

633572

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.479

High

633575

ERV41
ER-derived vesicles protein ERV41

1

7

Small-scale

0.479

High

633583

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

382828

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

569376

DPM1
Dolichol-phosphate mannosyltransferase

1

0

High-throughput

0.458

High

633556

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

633570

BECN1
Vacuolar protein sorting-associated protein 30

1

0

High-throughput

0.458

High

633584

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

633555

BNI1
Protein BNI1

1

7

High-throughput

0.457

High

633580

TLG2
t-SNARE affecting a late Golgi compartment protein 2

1

20

Small-scale

0.445

High

434819

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.437

High

441701

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

518201

IF4A
ATP-dependent RNA helicase eIF4A

1

7

High-throughput

0.437

High

558579

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

577524

CYC8
General transcriptional corepressor CYC8

1

2

Small-scale

0.437

High

633531

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.437

High

633532

SIS1
Protein SIS1

1

6

High-throughput

0.437

High

633536

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

633539

PRS6A
26S proteasome regulatory subunit 6A

1

9

High-throughput

0.437

High

633541

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

633543

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

633549

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

633558

MPS3
Spindle pole body assembly component MPS3

1

2

High-throughput

0.437

High

633576

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

633579

SUB2
ATP-dependent RNA helicase SUB2

1

10

High-throughput

0.437

High

633582

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.437

High

633552

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.407

High

633553

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.407

High

633586

CAF1A
Chromatin assembly factor 1 subunit A

1

4

High-throughput

0.407

High

633587

SET6
Potential protein lysine methyltransferase SET6

1

1

High-throughput

0.407

High

433445

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435770

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

454873

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

512817

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

633537

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

633560

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

633569

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

633574

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

633578

ATG23
Autophagy-related protein 23

1

0

High-throughput

0.249

Low

633581

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

597707

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025