HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: FGD5 (Q6ZNL6)
FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)
Gene: FGD5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.681

Property	Details
Experiments	33762435
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0032587 - ruffle membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1462
+	Mm
		964564 EGFR_MOUSE (1-1210): 0: 1258: 90.35		FGD5_MOUSE (253-1462): 0: 783: 76.50
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (806-1452): 1.28e-95: 331: 14.37
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (828-1404): 2.84e-89: 312: 14.70
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (828-1452): 2.24e-94: 326: 14.29
+	Hs
		338823 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q96D37_HUMAN (828-1452): 6.85e-95: 326: 14.29
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (486-1262): 3.75e-81: 297: 13.48
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (529-1237): 4.9e-81: 297: 12.44
+	Hs
		339121 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV3_HUMAN (827-1451): 2.85e-83: 294: 13.50
+	Hs
		855797 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV2_HUMAN (806-1452): 1.28e-95: 331: 14.37
+	Hs
		548711 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV_HUMAN (828-1452): 2.24e-94: 326: 14.29
+	Hs
		383705 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV2_HUMAN (806-1452): 1.28e-95: 331: 14.37
+	Hs
		383580 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV_HUMAN (828-1452): 2.24e-94: 326: 14.29
+	Hs
		383927 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q96D37_HUMAN (828-1452): 6.85e-95: 326: 14.29
+	Hs
		383561 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		BCR_HUMAN (476-1239): 1.79e-90: 323: 13.82
+	Hs
		1071026 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV3_HUMAN (827-1451): 2.85e-83: 294: 13.50
+	Hs
		548637 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		VAV_HUMAN (828-1452): 2.24e-94: 326: 14.29
+	Hs
		384022 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV3_HUMAN (827-1451): 2.85e-83: 294: 13.50
+	Hs
		224717 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		KALRN_HUMAN (839-1450): 2.09e-70: 264: 15.65
+	Hs
		338627 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ZFY16_HUMAN (1229-1385): 1.41e-11: 71.6: 30.82
+	Hs
		313484 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ZFYV9_HUMAN (1205-1296): 2.98e-09: 63.9: 38.04