HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CLNK (Q7Z7G1)
Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer)
Gene: CLNK

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 428
+	Mm
		957227 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SHC1_MOUSE (115-405): 5.6e-63: 214: 14.57
+	Hs
		338774 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC3_HUMAN (115-405): 1.15e-68: 230: 20.40
+	Rn
		1129188 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SHC1_RAT (115-405): 8.38e-70: 229: 14.24
+	Hs
		338278 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC2_HUMAN (115-405): 6.29e-64: 217: 15.59
+	Hs
		338753 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BLNK_HUMAN (61-417): 1.5e-64: 216: 22.70
+	Hs
		338356 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCP2_HUMAN (58-421): 5.56e-63: 213: 24.46
+	Hs
		337988 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC1_HUMAN (115-405): 5.33e-60: 207: 14.24
+	Hs
		338577 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC4_HUMAN (115-410): 5.83e-56: 197: 14.66
+	Hs
		338546 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHE_HUMAN (180-406): 9.96e-39: 147: 13.45
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (246-420): 1.77e-27: 117: 18.08
+	Hs
		339025 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH2B1_HUMAN (252-405): 2.99e-27: 116: 20.24
+	Hs
		145963 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH2B2_HUMAN (115-411): 9.73e-26: 111: 15.23
+	Hs
		339155 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH2B3_HUMAN (46-418): 3.49e-21: 97.8: 13.10
+	Mm
		719299 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN11_MOUSE (304-420): 2.88e-15: 79.7: 17.95
+	Hs
		337886 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG2_HUMAN (270-420): 3.64e-17: 86.2: 16.88
+	Hs
		337912 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG1_HUMAN (292-397): 7.5e-16: 82: 25.42
+	Hs
		338317 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN11_HUMAN (304-420): 2.88e-15: 79.7: 17.95
+	Hs
		145979 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		SH2B2_HUMAN (115-411): 9.73e-26: 111: 15.23
+	Hs
		562648 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PLCG2_HUMAN (270-420): 3.64e-17: 86.2: 16.88
+	Hs
		581010 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PLCG1_HUMAN (292-397): 7.5e-16: 82: 25.42