HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LRRT4 (Q86VH4)
Leucine-rich repeat transmembrane neuronal protein 4
Gene: LRRTM4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 590
+	Mm
		964570 EGFR_MOUSE (1-1210): 0: 1258: 90.35		LIGO1_MOUSE (9-423): 4.63e-75: 252: 21.58
+	Hs
		338833 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LIGO1_HUMAN (31-423): 1.96e-75: 253: 21.76
+	Hs
		338583 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG3_HUMAN (28-324): 2.53e-67: 239: 23.53
+	Hs
		299545 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG2_HUMAN (10-311): 1.03e-62: 225: 23.80
+	Hs
		1070977 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRIG3_HUMAN (28-324): 2.53e-67: 239: 23.53
+	Hs
		383860 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRIG3_HUMAN (28-324): 2.53e-67: 239: 23.53
+	At
		1352201 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		Y1723_ARATH (13-537): 2.7e-80: 275: 16.51
+	At
		83702 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		RGI3_ARATH (4-491): 1.18e-85: 290: 16.28
+	At
		795001 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		Y1723_ARATH (13-537): 2.7e-80: 275: 16.51
+	At
		83724 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		PXC2_ARATH (4-586): 2.37e-69: 243: 14.82
+	At
		249715 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		BAME3_ARATH (181-512): 1.65e-34: 141: 12.39
+	At
		83709 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		BAME3_ARATH (181-512): 1.65e-34: 141: 12.39
+	At
		221803 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME1_ARATH (312-531): 3.73e-20: 97: 6.28
+	At
		1338064 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		RGI1_ARATH (366-507): 1.77e-15: 82.3: 12.68
+	At
		221760 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		BAME1_ARATH (312-531): 3.73e-20: 97: 6.28
+	At
		1341092 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME2_ARATH (361-553): 3.02e-14: 78.1: 8.16
+	At
		84503 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		GSO1_ARATH (313-499): 6.26e-13: 74.2: 5.32
+	At
		83707 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		BAME1_ARATH (312-531): 3.73e-20: 97: 6.28
+	At
		84463 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		GSO1_ARATH (313-499): 6.26e-13: 74.2: 5.32
+	At
		83704 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		Y4361_ARATH (388-495): 9.81e-10: 63.8: 12.04