HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	25402006, 24658140, unassigned2173
Identification Methods	two hybrid, protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 347
+	Hs
		338903 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		338425 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		339132 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PACN2_HUMAN (1-343): 3.2e-38: 143: 16.45
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Hs
		338935 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRBS1_HUMAN (169-342): 1.13e-13: 74.1: 17.65
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		338633 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH3R1_HUMAN (271-339): 2.43e-11: 66.8: 20.83
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		298945 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15
+	Hs
		338526 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH319_HUMAN (291-342): 6.81e-09: 59.3: 48.08
+	Hs
		924589 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		383730 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		601876 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		434276 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		872730 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		PACN2_HUMAN (1-343): 3.2e-38: 143: 16.45
+	Hs
		434170 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		872610 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		872621 EPHB2_MOUSE (640-1067): 7.47e-121: 400: 28.09		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Hs
		872630 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38