Protein: WT1
Wilms tumor protein (WT33)

Gene: WT1
Organism: Homo sapiens
Interactions: 80
UniProt ID: P19544

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

612859

EGR1
Early growth response protein 1

2

18

Small-scale

0.768

High

624519

DVL3
Segment polarity protein dishevelled homolog DVL-3

3

11

High-throughput

0.671

High

624504

FL2D
Pre-mRNA-splicing regulator WTAP

4

0

Small-scale

0.670

High

624492

KR107
Keratin-associated protein 10-7

3

20

High-throughput

0.667

High

624511

HMBX1
Homeobox-containing protein 1

3

4

High-throughput

0.667

High

329173

RHIT
Transcriptional repressor RHIT

1

18

High-throughput

0.656

High

624512

TAOK1
Serine/threonine-protein kinase TAO1

1

6

High-throughput

0.656

High

624473

WT1
Wilms tumor protein

1

16

High-throughput

0.647

High

624506

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.647

High

624524

GLIS2
Zinc finger protein GLIS2

1

17

High-throughput

0.647

High

413168

P53
Cellular tumor antigen p53

3

7

Small-scale

0.646

High

159502

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

10

High-throughput

0.640

High

624509

K1C40
Keratin, type I cytoskeletal 40

2

10

High-throughput

0.628

High

624488

KR103
Keratin-associated protein 10-3

2

20

High-throughput

0.613

High

189105

IPO8
Importin-8

2

20

High-throughput

0.606

High

624490

KR106
Keratin-associated protein 10-6

2

20

High-throughput

0.606

High

624525

OSBL3
Oxysterol-binding protein-related protein 3

2

1

High-throughput

0.606

High

624527

PICK1
PRKCA-binding protein

2

7

High-throughput

0.606

High

624529

ZRAN1
Ubiquitin thioesterase ZRANB1

2

11

High-throughput

0.606

High

154936

BHE40
Class E basic helix-loop-helix protein 40

2

0

High-throughput

0.580

High

624510

TET2
Methylcytosine dioxygenase TET2

1

4

Small-scale

0.578

High

302745

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

13

Small-scale

0.573

High

624478

U2AF2
Splicing factor U2AF 65 kDa subunit

1

7

Small-scale

0.573

High

624495

UBC9
SUMO-conjugating enzyme UBC9

1

6

Small-scale

0.573

High

624521

PAWR
PRKC apoptosis WT1 regulator protein

1

1

Small-scale

0.573

High

624493

KR108
Keratin-associated protein 10-8

1

20

High-throughput

0.573

High

70112

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

142485

IMA3
Importin subunit alpha-3

1

8

High-throughput

0.541

High

179024

IMA6
Importin subunit alpha-6

1

8

High-throughput

0.541

High

343735

LDOC1
Protein LDOC1

1

3

High-throughput

0.541

High

562866

CCL5
C-C motif chemokine 5

1

1

High-throughput

0.541

High

624482

MAGA8
Melanoma-associated antigen 8

1

4

High-throughput

0.541

High

624487

KR101
Keratin-associated protein 10-1

1

20

High-throughput

0.541

High

624494

KR109
Keratin-associated protein 10-9

1

20

High-throughput

0.541

High

624497

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

High-throughput

0.541

High

624514

FAM9B
Protein FAM9B

1

3

High-throughput

0.541

High

624517

CEP70
Centrosomal protein of 70 kDa

1

4

High-throughput

0.541

High

624518

THRSP
Thyroid hormone-inducible hepatic protein

1

2

High-throughput

0.541

High

624523

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

624528

THAP1
THAP domain-containing protein 1

1

5

High-throughput

0.541

High

624530

ETV7
Transcription factor ETV7

1

19

High-throughput

0.541

High

539919

ARY2
Arylamine N-acetyltransferase 2

1

0

High-throughput

0.518

High

624496

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.518

High

624503

IDI1
Isopentenyl-diphosphate Delta-isomerase 1

1

0

High-throughput

0.518

High

624508

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.518

High

624513

CASZ1
Zinc finger protein castor homolog 1

1

0

High-throughput

0.518

High

374390

RASH
GTPase HRas

1

6

High-throughput

0.515

High

421475

A4
Amyloid-beta precursor protein

1

20

High-throughput

0.515

High

593724

PECA1
Platelet endothelial cell adhesion molecule

1

1

High-throughput

0.515

High

624476

DNJB1
DnaJ homolog subfamily B member 1

1

7

High-throughput

0.515

High

624502

SQSTM
Sequestosome-1

1

5

High-throughput

0.515

High

288582

NPM3
Nucleoplasmin-3

1

5

High-throughput

0.508

High

185420

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

371136

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.501

High

624483

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.501

High

624499

SOX4
Transcription factor SOX-4

1

20

High-throughput

0.501

High

340979

DIRA3
GTP-binding protein Di-Ras3

1

5

High-throughput

0.494

High

624486

KLK7
Kallikrein-7

1

2

High-throughput

0.494

High

624500

GOGA2
Golgin subfamily A member 2

1

13

High-throughput

0.494

High

624522

CC136
Coiled-coil domain-containing protein 136

1

2

High-throughput

0.494

High

624479

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

624481

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

624520

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.481

High

128770

MEN1
Menin

1

2

Small-scale

0.479

High

624474

TA2R
Thromboxane A2 receptor

1

2

Small-scale

0.479

High

624477

DNMT1
DNA

1

14

Small-scale

0.479

High

624480

HSP74
Heat shock 70 kDa protein 4

1

14

Small-scale

0.479

High

624484

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

High-throughput

0.479

High

624485

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.479

High

624498

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

624507

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

Small-scale

0.479

High

624526

NANOG
Homeobox protein NANOG

1

9

High-throughput

0.479

High

624475

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.470

High

624505

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.458

High

624489

KR105
Keratin-associated protein 10-5

1

20

High-throughput

0.457

High

624491

KR104
Keratin-associated protein 10-4

1

20

High-throughput

0.457

High

624501

GRIK2
Glutamate receptor ionotropic, kainate 2

1

1

High-throughput

0.417

High

624515

FMR1N
FMR1 neighbor protein

1

0

High-throughput

0.282

High

624516

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025