HitPredict

Interactor 1: CDK1 (P00546)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (Cell division control protein 28) (Cell division protein kinase 1)
Gene: CDC28

Interactor 2: FKH2 (P41813)
Fork head protein homolog 2
Gene: FKH2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	14574415, 15509804
Identification Methods	protein kinase assay, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FHA~Pkinase
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 298 Sc			1 862
+	Sc
		339677 CDK1_YEAST (1-298): 1.93e-142: 404: 100.00		FKH1_YEAST (22-504): 4.81e-117: 366: 42.89
+	Hs
		625387 CDK2_HUMAN (5-297): 1.27e-155: 437: 62.12		FOXM1_HUMAN (219-788): 8.38e-63: 228: 16.31
+	Hs
		414889 CDK1_HUMAN (5-297): 1.32e-141: 402: 59.73		FOXM1_HUMAN (219-788): 8.38e-63: 228: 16.31
+	Hs
		414840 CDK1_HUMAN (5-297): 1.32e-141: 402: 59.73		FOXA1_HUMAN (234-607): 1.41e-55: 201: 16.03
+	Hs
		414893 CDK1_HUMAN (5-297): 1.32e-141: 402: 59.73		FOXO1_HUMAN (196-746): 8.31e-52: 194: 14.66
+	Hs
		178959 CDK3_HUMAN (5-295): 4.65e-147: 416: 63.92		FOXP2_HUMAN (193-557): 1.87e-44: 173: 18.36
+	Sc
		339463 CDK1_YEAST (1-298): 1.93e-142: 404: 100.00		HCM1_YEAST (240-796): 5.01e-45: 173: 15.45
+	Ca
		793057 CDK1_CANAL (4-295): 4.58e-140: 399: 79.45		FKH2_CANAL (25-581): 7.97e-34: 141: 23.39
+	Sp
		223988 CDK1_SCHPO (5-297): 6.59e-134: 382: 63.21		FKH2_SCHPO (31-587): 4e-34: 141: 17.00