HitPredict

Interactor 1: FOS (P01100)
Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)
Gene: FOS

Interactor 2: MK09 (P45984)
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
Gene: MAPK9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25609649
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0034614 - cellular response to reactive oxygen species GO:0071276 - cellular response to cadmium ion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 424
+	Hs
		345416 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		MK07_HUMAN (16-385): 3.24e-132: 401: 37.53
+	Hs
		547743 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK09_HUMAN (1-424): 2.83e-163: 467: 100.00
+	Mm
		562984 ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62		MK09_MOUSE (1-424): 1.69e-161: 463: 96.70
+	Hs
		547757 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK10_HUMAN (1-424): 1.16e-155: 449: 84.04
+	Hs
		568251 ATF7_HUMAN (82-289): 7.9e-31: 124: 16.59		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Dm
		599213 FOSLA_DROME (33-379): 5.55e-44: 164: 19.66		JNK_DROME (9-373): 5.65e-138: 401: 74.32
+	Hs
		547742 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Hs
		111278 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		J3KNK1_HUMAN (288-424): 7.41e-89: 274: 97.81
+	Mm
		562982 ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62		MK08_MOUSE (1-380): 8.38e-145: 419: 83.42
+	Hs
		345341 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Hs
		173828 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK13_HUMAN (10-365): 2.72e-135: 394: 46.93
+	Hs
		547805 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK11_HUMAN (8-363): 3.93e-133: 388: 47.08
+	Hs
		579344 ATF6A_HUMAN (4-318): 1.09e-31: 128: 14.03		MK14_HUMAN (4-375): 9.3e-130: 379: 48.00
+	Rn
		102456 ATF2_RAT (4-293): 3.18e-29: 119: 18.62		G3V617_RAT (4-375): 2.38e-130: 381: 48.00
+	Hs
		547811 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK14_HUMAN (4-375): 9.3e-130: 379: 48.00
+	Mm
		562973 ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62		MK14_MOUSE (4-375): 3.76e-130: 381: 48.00
+	Ce
		105174 FOS1_CAEEL (40-301): 1e-33: 132: 17.88		KGB1_CAEEL (8-364): 1.62e-119: 355: 49.05
+	Hs
		547713 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Mm
		562980 ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62		MK03_MOUSE (20-370): 8.49e-83: 260: 40.56
+	Mm
		562975 ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62		MK01_MOUSE (15-364): 3.12e-82: 258: 40.22