HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0032991 - protein-containing complex GO:0043066 - negative regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 654
+	Hs
		346070 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HS71L_HUMAN (24-647): 0: 922: 63.16
+	Hs
		345782 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		345856 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HSP76_HUMAN (25-635): 0: 915: 62.54
+	Hs
		346325 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HSP72_HUMAN (25-636): 0: 905: 64.51
+	Hs
		378955 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		378953 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		BIP_HUMAN (19-654): 0: 914: 100.00
+	Dm
		669839 MYC_DROME (210-454): 3.25e-30: 126: 26.74		BIP_DROME (27-654): 0: 989: 82.86
+	Hs
		379164 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		HSP72_HUMAN (25-636): 0: 905: 64.51
+	Hs
		502025 SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54		BIP_HUMAN (19-654): 0: 914: 100.00