HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: PRDX3 (P30048)
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
Gene: PRDX3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008284 - positive regulation of cell population proliferation GO:0032991 - protein-containing complex GO:0043066 - negative regulation of apoptotic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 256
+	Hs
		346054 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13
+	Hs
		346680 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82
+	Hs
		346608 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54
+	Hs
		346021 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25
+	Hs
		379048 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00
+	Hs
		379061 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13
+	Hs
		379355 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82
+	Hs
		379319 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54
+	Hs
		379047 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25