Protein: CNN3
Calponin-3 (Calponin, acidic isoform)

Gene: CNN3
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q15417

Gene Ontology (top 5):
GO:0005516 - calmodulin binding
GO:0005829 - cytosol
GO:0005912 - adherens junction
GO:0005925 - focal adhesion
GO:0007015 - actin filament organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1148315

CNN2
Calponin-2

3

12

High-throughput

0.861

High

840884

TEC
Tyrosine-protein kinase Tec

1

5

High-throughput

0.691

High

1148307

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

2

High-throughput

0.691

High

241759

PRKN
E3 ubiquitin-protein ligase parkin

3

8

High-throughput

0.640

High

537202

HSP7C
Heat shock cognate 71 kDa protein

3

3

High-throughput

0.624

High

952837

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

995611

ACTC
Actin, alpha cardiac muscle 1

1

18

High-throughput

0.618

High

1148329

TES
Testin

1

18

High-throughput

0.618

High

1148305

CARM1
Histone-arginine methyltransferase CARM1

2

1

High-throughput

0.601

High

791407

SYUA
Alpha-synuclein

2

5

High-throughput

0.586

High

862156

YAP1
Transcriptional coactivator YAP1

2

15

Small-scale

0.584

High

989902

CANB1
Calcineurin subunit B type 1

1

9

High-throughput

0.575

High

1086160

CETN1
Centrin-1

1

12

High-throughput

0.575

High

1148298

CDC73
Parafibromin

2

2

High-throughput

0.571

High

529849

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.554

High

411981

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.553

High

1148299

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.553

High

1109750

HDAC1
Histone deacetylase 1

1

8

High-throughput

0.536

High

1148323

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

1123195

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.515

High

936053

PAR2
Proteinase-activated receptor 2

1

2

High-throughput

0.494

High

345862

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

487345

PARP1
Poly [ADP-ribose] polymerase 1

1

13

High-throughput

0.479

High

535095

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.479

High

556099

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

830791

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

867154

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.479

High

894767

EMD
Emerin

1

1

Small-scale

0.479

High

970553

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

976283

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.479

High

1062474

DHX9
ATP-dependent RNA helicase A

1

3

Small-scale

0.479

High

1067359

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

1094556

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

High-throughput

0.479

High

1100793

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

1107741

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

1140314

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1148295

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

5

High-throughput

0.479

High

1148303

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1148308

BICD2
Protein bicaudal D homolog 2

1

16

High-throughput

0.479

High

1148310

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

High-throughput

0.479

High

1148311

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.479

High

1148314

BICD1
Protein bicaudal D homolog 1

1

11

High-throughput

0.479

High

1148318

TRI31
E3 ubiquitin-protein ligase TRIM31

1

13

High-throughput

0.479

High

1148319

WWTR1
WW domain-containing transcription regulator protein 1

1

11

High-throughput

0.479

High

1148327

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

1148328

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

642887

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.470

High

1148325

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

328023

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.445

High

563808

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.445

High

701987

TMOD1
Tropomodulin-1

1

5

High-throughput

0.445

High

1082542

NEXN
Nexilin

1

5

High-throughput

0.445

High

1141446

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

1

High-throughput

0.445

High

1148296

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1148297

PKHA7
Pleckstrin homology domain-containing family A member 7

1

16

High-throughput

0.445

High

1148304

LUZP1
Leucine zipper protein 1

1

17

High-throughput

0.445

High

1148312

TRI11
E3 ubiquitin-protein ligase TRIM11

1

1

High-throughput

0.445

High

1148320

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

1148321

ATG5
Autophagy protein 5

1

2

High-throughput

0.445

High

1148324

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

1148332

COR2B
Coronin-2B

1

8

High-throughput

0.445

High

315618

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.437

High

372099

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

588771

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.437

High

695536

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

768265

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

944999

RAB25
Ras-related protein Rab-25

1

6

High-throughput

0.437

High

1096697

RFA4
Replication protein A 30 kDa subunit

1

8

High-throughput

0.437

High

1148301

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

1148302

CLC14
C-type lectin domain family 14 member A

1

1

Small-scale

0.437

High

1148322

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.437

High

1148326

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

5

High-throughput

0.437

High

1148330

DS13B
Dual specificity protein phosphatase 13B

1

4

High-throughput

0.437

High

1148331

WASF3
Actin-binding protein WASF3

1

1

High-throughput

0.437

High

1148313

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

1148317

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.426

High

332303

ATE1
Arginyl-tRNA--protein transferase 1

1

1

High-throughput

0.407

High

1103181

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.407

High

1148300

NEK10
Serine/threonine-protein kinase Nek10

1

4

High-throughput

0.407

High

1148306

SLX4
Structure-specific endonuclease subunit SLX4

1

8

High-throughput

0.407

High

505162

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

1148309

YLAT2
Y+L amino acid transporter 2

1

0

High-throughput

0.279

Low

1148316

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

1148294

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025