HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	30415952, 35013218, 36424410
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 526
+	Hs
		347491 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		346559 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		348237 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		348368 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Hs
		346697 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Hs
		345797 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		346316 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SC24C_HUMAN (1-262): 5.36e-11: 67.4: 14.34
+	Hs
		379677 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		379073 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		379305 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		380019 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		380076 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Hs
		726850 USF2_HUMAN (180-454): 1.78e-35: 136: 15.99		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		607809 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		379365 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Hs
		378957 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		379162 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SC24C_HUMAN (1-262): 5.36e-11: 67.4: 14.34
+	Mm
		1142805 SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61		EWS_MOUSE (3-451): 2.8e-30: 127: 35.56
+	Hs
		726694 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Dm
		1099595 Q9W4Q7_DROME (358-449): 5.64e-19: 91.7: 29.03		CAZ_DROME (175-481): 5.46e-34: 134: 38.91