HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

The method score is based on:

Property	Details
Experiments	22190494, 21807113
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, deacetylase assay
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 9 others more... GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0006974 - DNA damage response GO:0008284 - positive regulation of cell population proliferation GO:0043066 - negative regulation of apoptotic process GO:0043280 - positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0071456 - cellular response to hypoxia GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	454
Hs

1	747

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024