HitPredict

Interactor 1: HSP7C (P63017)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8)
Gene: Hspa8

Interactor 2: BAG3 (Q9JLV1)
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis)
Gene: BAG3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20884878
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BAG~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0034605 - cellular response to heat GO:0061684 - chaperone-mediated autophagy
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Mm			1 577
+	Hs
		347871 Q96IS6_HUMAN (60-646): 0: 1124: 99.83		BAG3_HUMAN (1-577): 0: 729: 83.31
+	Mm
		609032 HS71B_MOUSE (1-646): 0: 959: 84.06		BAG3_MOUSE (1-577): 0: 849: 100.00
+	Hs
		347494 HSP7C_HUMAN (1-646): 0: 972: 99.85		BAG3_HUMAN (1-577): 0: 729: 83.31
+	Hs
		347555 HS71L_HUMAN (2-646): 0: 969: 82.64		BAG3_HUMAN (1-577): 0: 729: 83.31
+	Hs
		347515 HSP76_HUMAN (6-646): 0: 958: 77.54		BAG3_HUMAN (1-577): 0: 729: 83.31
+	Hs
		347739 Q53FC7_HUMAN (6-646): 0: 954: 77.07		BAG3_HUMAN (1-577): 0: 729: 83.31
+	Hs
		347489 HS71A_HUMAN (1-646): 0: 951: 84.52		BAG3_HUMAN (1-577): 0: 729: 83.31
+	Hs
		347599 HSP72_HUMAN (2-646): 0: 943: 85.01		BAG3_HUMAN (1-577): 0: 729: 83.31
+	Hs
		336616 HSP7C_HUMAN (1-646): 0: 972: 99.85		BAG4_HUMAN (386-504): 6.85e-36: 141: 45.38
+	Hs
		336630 HS71L_HUMAN (2-646): 0: 969: 82.64		BAG4_HUMAN (386-504): 6.85e-36: 141: 45.38
+	Mm
		609028 HS71B_MOUSE (1-646): 0: 959: 84.06		BAG4_MOUSE (386-504): 1.71e-39: 151: 47.90
+	Hs
		336621 HSP76_HUMAN (6-646): 0: 958: 77.54		BAG4_HUMAN (386-504): 6.85e-36: 141: 45.38
+	Hs
		336682 Q53FC7_HUMAN (6-646): 0: 954: 77.07		BAG4_HUMAN (386-504): 6.85e-36: 141: 45.38
+	Hs
		336646 HSP72_HUMAN (2-646): 0: 943: 85.01		BAG4_HUMAN (386-504): 6.85e-36: 141: 45.38
+	Hs
		538096 HSP7C_HUMAN (1-646): 0: 972: 99.85		BAG5_HUMAN (423-503): 3.97e-17: 86: 43.21
+	Mm
		989273 HSP7C_MOUSE (1-646): 0: 971: 100.00		BAG5_MOUSE (419-503): 1.7e-16: 84.1: 42.35
+	Hs
		761536 HS71L_HUMAN (2-646): 0: 969: 82.64		BAG5_HUMAN (423-503): 3.97e-17: 86: 43.21
+	Hs
		600958 HSP76_HUMAN (6-646): 0: 958: 77.54		BAG5_HUMAN (423-503): 3.97e-17: 86: 43.21
+	Mm
		609027 HS71B_MOUSE (1-646): 0: 959: 84.06		BAG5_MOUSE (419-503): 1.7e-16: 84.1: 42.35
+	Hs
		1198803 Q53FC7_HUMAN (6-646): 0: 954: 77.07		BAG5_HUMAN (423-503): 3.97e-17: 86: 43.21