HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: SMC6 (Q96SB8)
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Gene: SMC6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21150319
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0032204 - regulation of telomere maintenance
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 1091
+	Hs
		311454 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMC2_HUMAN (46-1069): 6.98e-59: 223: 13.19
+	Hs
		348261 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77
+	Hs
		348010 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMC4_HUMAN (2-977): 1e-39: 162: 10.55
+	Hs
		346097 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MYH11_HUMAN (455-985): 4.02e-25: 115: 11.09
+	Hs
		345843 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		DESP_HUMAN (126-744): 7.41e-23: 108: 8.27
+	Hs
		346089 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MYH10_HUMAN (472-979): 2.06e-21: 103: 10.92
+	Hs
		346088 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MYH9_HUMAN (588-990): 2.42e-19: 96.6: 12.90
+	Hs
		311457 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMC2_HUMAN (46-1069): 6.98e-59: 223: 13.19
+	Hs
		1218677 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		SMC5_HUMAN (5-1069): 1.28e-69: 255: 16.18
+	Hs
		379920 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMC4_HUMAN (2-977): 1e-39: 162: 10.55
+	Hs
		1218737 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77
+	Hs
		378986 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		DESP_HUMAN (126-744): 7.41e-23: 108: 8.27
+	Hs
		840228 MXI1_HUMAN (321-450): 2.55e-29: 116: 27.69		SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77
+	Hs
		983450 MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40		SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77
+	Hs
		379071 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		MYH10_HUMAN (472-979): 2.06e-21: 103: 10.92
+	Hs
		1055889 MAD4_HUMAN (320-449): 5.66e-28: 112: 23.85		SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77
+	Hs
		379070 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		MYH9_HUMAN (588-990): 2.42e-19: 96.6: 12.90
+	Hs
		1314327 MAD3_HUMAN (320-450): 1.2e-25: 105: 26.72		SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77