HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: BIG2 (Q9Y6D5)
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
Gene: ARFGEF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1785
+	Hs
		1070486 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		BIG2_HUMAN (1-1785): 0: 1997: 100.00
+	Hs
		349770 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		BIG2_HUMAN (1-1785): 0: 1997: 100.00
+	Hs
		914498 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		BIG2_HUMAN (1-1785): 0: 1997: 100.00
+	Hs
		349771 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		914499 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		895339 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		350612 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PSD3_HUMAN (202-1074): 2.97e-179: 571: 13.83
+	Hs
		1070421 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		PSD3_HUMAN (202-1074): 2.97e-179: 571: 13.83
+	Hs
		348966 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		PSD3_HUMAN (202-1074): 2.97e-179: 571: 13.83
+	Hs
		914406 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		PSD3_HUMAN (202-1074): 2.97e-179: 571: 13.83
+	Hs
		895298 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		PSD3_HUMAN (202-1074): 2.97e-179: 571: 13.83
+	Hs
		349496 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PSD4_HUMAN (579-1072): 2.1e-111: 383: 15.77
+	Hs
		894784 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31
+	Hs
		349536 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31
+	Dm
		53567 O18332_DROME (4-186): 3.58e-74: 223: 32.31		A1Z8W9_DROME (1278-1514): 4.05e-46: 185: 12.45
+	Hs
		914254 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31
+	Hs
		895210 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31
+	Hs
		1070237 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		BIG3_HUMAN (15-231): 2.83e-33: 143: 21.88
+	Hs
		914170 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		MON2_HUMAN (11-228): 1.82e-35: 150: 14.61
+	Hs
		895121 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		BIG3_HUMAN (15-231): 2.83e-33: 143: 21.88