HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30442766, 30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000165 - MAPK cascade GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0046330 - positive regulation of JNK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1332
+	Hs
		348783 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		350342 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		348995 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		350664 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		349719 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324709 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324711 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324774 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324710 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		348748 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		350286 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		914159 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		349425 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		348766 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		350320 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		914500 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		STK24_HUMAN (20-443): 5.39e-117: 374: 34.98
+	Hs
		349428 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		NRK_HUMAN (1-865): 2.05e-105: 369: 28.26
+	Dm
		442965 RAP1_DROME (1-163): 4.53e-64: 197: 58.54		HIPPO_DROME (16-374): 2.99e-115: 377: 37.09
+	Hs
		350725 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		914488 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60