Protein: CD63
CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)

Gene: CD63
Organism: Homo sapiens
Interactions: 116
UniProt ID: P08962

Gene Ontology (top 5):
GO:0002092 - positive regulation of receptor internalization
GO:0005615 - extracellular space
GO:0005654 - nucleoplasm
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

477403

CD9
CD9 antigen

3

19

Small-scale

0.817

High

252580

TSN2
Tetraspanin-2

2

19

High-throughput

0.811

High

369995

TIMP1
Metalloproteinase inhibitor 1

4

1

Small-scale

0.700

High

349362

TSN15
Tetraspanin-15

1

16

High-throughput

0.691

High

477415

TSN31
Tetraspanin-31

1

2

High-throughput

0.691

High

477399

LEG3
Galectin-3

4

10

High-throughput

0.691

High

477434

RETR3
Reticulophagy regulator 3

4

7

High-throughput

0.691

High

125166

LEG9
Galectin-9

3

10

High-throughput

0.667

High

127255

LEG8
Galectin-8

3

10

High-throughput

0.667

High

477424

WLS
Protein wntless homolog

3

5

Small-scale

0.656

High

431667

ITB1
Integrin beta-1

3

19

Small-scale

0.640

High

252650

TSN3
Tetraspanin-3

1

17

High-throughput

0.618

High

477405

CD82
CD82 antigen

1

19

Small-scale

0.618

High

477478

FPRP
Prostaglandin F2 receptor negative regulator

1

20

Small-scale

0.618

High

220466

RNF13
E3 ubiquitin-protein ligase RNF13

2

7

High-throughput

0.611

High

477420

SC5A9
Sodium/glucose cotransporter 4

2

4

High-throughput

0.601

High

140116

SDCB1
Syntenin-1

2

2

Small-scale

0.595

High

160978

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

High-throughput

0.575

High

477412

PAR2
Proteinase-activated receptor 2

1

19

High-throughput

0.541

High

180471

PLS1
Phospholipid scramblase 1

1

4

High-throughput

0.536

High

190583

MRP4
ATP-binding cassette sub-family C member 4

1

2

High-throughput

0.536

High

248552

FADS1
Acyl-CoA

1

4

High-throughput

0.536

High

275483

RTN2
Reticulon-2

1

4

High-throughput

0.536

High

477395

SC5A1
Sodium/glucose cotransporter 1

1

4

High-throughput

0.536

High

477397

NCPR
NADPH--cytochrome P450 reductase

1

3

High-throughput

0.536

High

477402

SYT1
Synaptotagmin-1

1

2

High-throughput

0.536

High

477404

FPR2
N-formyl peptide receptor 2

1

17

High-throughput

0.536

High

477406

CALX
Calnexin

1

5

High-throughput

0.536

High

477414

KDSR
3-ketodihydrosphingosine reductase

1

11

High-throughput

0.536

High

477418

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.536

High

477419

CP2AD
Cytochrome P450 2A13

1

1

High-throughput

0.536

High

477423

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

5

High-throughput

0.536

High

477425

ZDH20
Palmitoyltransferase ZDHHC20

1

9

High-throughput

0.536

High

477426

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

1

High-throughput

0.536

High

477430

S27A4
Long-chain fatty acid transport protein 4

1

6

High-throughput

0.536

High

477444

YIPF5
Protein YIPF5

1

1

High-throughput

0.536

High

477446

F241B
Protein FAM241B

1

2

High-throughput

0.536

High

477447

HVCN1
Voltage-gated hydrogen channel 1

1

5

High-throughput

0.536

High

477462

TMM43
Transmembrane protein 43

1

2

High-throughput

0.536

High

477466

CCG6
Voltage-dependent calcium channel gamma-6 subunit

1

1

High-throughput

0.536

High

477469

LMA2L
VIP36-like protein

1

2

High-throughput

0.536

High

477476

PDXL2
Podocalyxin-like protein 2

1

1

High-throughput

0.536

High

477477

GPC5B
G-protein coupled receptor family C group 5 member B

1

4

High-throughput

0.536

High

344450

STR3N
STARD3 N-terminal-like protein

1

0

High-throughput

0.513

High

477416

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

High-throughput

0.513

High

477428

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

0

High-throughput

0.513

High

477461

TMM47
Transmembrane protein 47

1

0

High-throughput

0.513

High

477463

TM208
Transmembrane protein 208

1

0

High-throughput

0.513

High

477467

YIPF3
Protein YIPF3

1

0

High-throughput

0.513

High

477400

SDC1
Syndecan-1

1

3

Small-scale

0.501

High

170633

CLGN
Calmegin

1

5

High-throughput

0.489

High

477410

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

477422

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

4

High-throughput

0.489

High

477427

LEG9C
Galectin-9C

1

10

High-throughput

0.489

High

477429

MBOA5
Lysophospholipid acyltransferase 5

1

3

High-throughput

0.489

High

477431

LCLT1
Lysocardiolipin acyltransferase 1

1

15

High-throughput

0.489

High

477437

GHDC
GH3 domain-containing protein

1

5

High-throughput

0.489

High

477439

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

3

High-throughput

0.489

High

477441

BRI3B
BRI3-binding protein

1

2

High-throughput

0.489

High

477443

CDS1
Phosphatidate cytidylyltransferase 1

1

3

High-throughput

0.489

High

477445

T4S18
Transmembrane 4 L6 family member 18

1

1

High-throughput

0.489

High

477448

TV23C
Golgi apparatus membrane protein TVP23 homolog C

1

2

High-throughput

0.489

High

477449

ALG14
UDP-N-acetylglucosamine transferase subunit ALG14

1

1

High-throughput

0.489

High

477450

CERS2
Ceramide synthase 2

1

3

High-throughput

0.489

High

477453

REEP6
Receptor expression-enhancing protein 6

1

6

High-throughput

0.489

High

477454

F210B
Protein FAM210B, mitochondrial

1

7

High-throughput

0.489

High

477455

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

3

High-throughput

0.489

High

477456

F210A
Protein FAM210A

1

7

High-throughput

0.489

High

477458

SGMR1
Sigma non-opioid intracellular receptor 1

1

1

High-throughput

0.489

High

477470

REEP4
Receptor expression-enhancing protein 4

1

6

High-throughput

0.489

High

477471

ZDHC6
Palmitoyltransferase ZDHHC6

1

13

High-throughput

0.489

High

477472

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.489

High

477482

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

1

High-throughput

0.489

High

183904

S22A2
Solute carrier family 22 member 2

1

6

Small-scale

0.481

High

184000

S22A1
Solute carrier family 22 member 1

1

6

Small-scale

0.481

High

477409

GLP1R
Glucagon-like peptide 1 receptor

1

14

Small-scale

0.481

High

327748

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

Small-scale

0.479

High

380248

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

8

Small-scale

0.479

High

477390

KIT
Mast/stem cell growth factor receptor Kit

1

7

Small-scale

0.479

High

477391

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

477393

SRC
Proto-oncogene tyrosine-protein kinase Src

1

2

Small-scale

0.479

High

477394

DOB
HLA class II histocompatibility antigen, DO beta chain

1

7

Small-scale

0.479

High

477396

VATB1
V-type proton ATPase subunit B, kidney isoform

1

1

High-throughput

0.479

High

477407

DMB
HLA class II histocompatibility antigen, DM beta chain

1

8

Small-scale

0.479

High

477435

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

477436

TM192
Transmembrane protein 192

1

3

High-throughput

0.479

High

477459

TS101
Tumor susceptibility gene 101 protein

1

1

Small-scale

0.479

High

477465

CLC7A
C-type lectin domain family 7 member A

1

13

Small-scale

0.479

High

477392

SRF
Serum response factor

1

0

Small-scale

0.460

High

128128

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

Small-scale

0.458

High

477479

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

217304

PROM1
Prominin-1

1

1

Small-scale

0.457

High

477442

TSC1
Hamartin

1

4

Small-scale

0.457

High

477398

ANFB
Natriuretic peptides B

1

1

High-throughput

0.445

High

477408

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.445

High

477413

S35B1
Solute carrier family 35 member B1

1

3

High-throughput

0.445

High

477421

S35G1
Solute carrier family 35 member G1

1

1

High-throughput

0.445

High

477473

ZDH11
Palmitoyltransferase ZDHHC11

1

15

High-throughput

0.445

High

477475

DDX28
Probable ATP-dependent RNA helicase DDX28

1

4

High-throughput

0.445

High

477460

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

5

Small-scale

0.439

High

477432

GDPD4
Glycerophosphodiester phosphodiesterase domain-containing protein 4

1

1

High-throughput

0.437

High

477433

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

477440

RN149
E3 ubiquitin-protein ligase RNF149

1

8

High-throughput

0.437

High

477468

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

Small-scale

0.437

High

477457

DIRC2
Solute carrier family 49 member 4

1

0

High-throughput

0.426

High

477417

MFS10
Major facilitator superfamily domain-containing protein 10

1

8

High-throughput

0.407

High

477451

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

2

High-throughput

0.407

High

477452

TMM80
Transmembrane protein 80

2

0

High-throughput

0.316

High

477411

BPL1
Biotin--protein ligase

1

0

High-throughput

0.279

Low

477438

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

477464

ABHEA
Protein ABHD14A

1

0

High-throughput

0.279

Low

477474

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

0

High-throughput

0.279

Low

477480

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.279

Low

477481

DOLK
Dolichol kinase

1

0

High-throughput

0.279

Low

116325

PIRC2
Piercer of microtubule wall 2 protein

1

0

High-throughput

0.249

Low

477401

HXK1
Hexokinase-1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025