Protein: TSN3
Tetraspanin-3 (Tspan-3) (Tetraspanin TM4-A) (Transmembrane 4 superfamily member 8)

Gene: TSN3, TSPAN3
Organism: Homo sapiens
Interactions: 102
UniProt ID: O60637

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0070062 - extracellular exosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

252570

TSN2
Tetraspanin-2

2

19

High-throughput

0.811

High

252648

TSN15
Tetraspanin-15

1

18

High-throughput

0.691

High

163210

TR10B
Tumor necrosis factor receptor superfamily member 10B

3

2

High-throughput

0.667

High

225876

STX6
Syntaxin-6

3

3

High-throughput

0.667

High

252651

FGFR1
Fibroblast growth factor receptor 1

3

6

High-throughput

0.667

High

252658

FGFR2
Fibroblast growth factor receptor 2

3

7

High-throughput

0.667

High

252670

EPHA5
Ephrin type-A receptor 5

3

6

High-throughput

0.667

High

252671

EPHA4
Ephrin type-A receptor 4

3

7

High-throughput

0.667

High

252685

C2D1A
Coiled-coil and C2 domain-containing protein 1A

3

2

High-throughput

0.667

High

252692

GOGA7
Golgin subfamily A member 7

3

1

High-throughput

0.667

High

252706

LPAR1
Lysophosphatidic acid receptor 1

3

18

High-throughput

0.667

High

252725

CD320
CD320 antigen

3

11

High-throughput

0.667

High

252731

NOTC3
Neurogenic locus notch homolog protein 3

3

1

High-throughput

0.667

High

252714

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

3

0

High-throughput

0.638

High

252697

RN149
E3 ubiquitin-protein ligase RNF149

4

8

High-throughput

0.633

High

252659

NK1R
Substance-P receptor

2

10

High-throughput

0.628

High

252669

EFNB2
Ephrin-B2

2

3

High-throughput

0.628

High

252681

CC50B
Cell cycle control protein 50B

2

2

High-throughput

0.628

High

252686

LRC8B
Volume-regulated anion channel subunit LRRC8B

2

3

High-throughput

0.628

High

252693

GP141
Probable G-protein coupled receptor 141

2

14

High-throughput

0.628

High

252695

AGRG5
Adhesion G-protein coupled receptor G5

2

13

High-throughput

0.628

High

252710

GPR21
Probable G-protein coupled receptor 21

2

10

High-throughput

0.628

High

252718

ABCG8
ATP-binding cassette sub-family G member 8

2

1

High-throughput

0.628

High

252730

TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme

2

3

High-throughput

0.628

High

252650

CD63
CD63 antigen

1

17

High-throughput

0.618

High

140075

SDCB1
Syntenin-1

2

2

High-throughput

0.611

High

252647

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

3

High-throughput

0.611

High

64570

MP3B2
Microtubule-associated protein 1 light chain 3 beta 2

3

3

High-throughput

0.609

High

220457

RNF13
E3 ubiquitin-protein ligase RNF13

3

7

High-throughput

0.609

High

252713

NFIP1
NEDD4 family-interacting protein 1

3

1

High-throughput

0.609

High

252733

ZDHC9
Palmitoyltransferase ZDHHC9

3

10

High-throughput

0.609

High

252699

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

252694

ARL17
ADP-ribosylation factor-like protein 17

2

0

High-throughput

0.585

High

125097

LEG9
Galectin-9

2

10

High-throughput

0.574

High

252684

LEG9C
Galectin-9C

2

10

High-throughput

0.574

High

252717

LMA2L
VIP36-like protein

2

2

High-throughput

0.574

High

252673

EREP3
Protein ENTREP3

2

1

High-throughput

0.558

High

252675

KDSR
3-ketodihydrosphingosine reductase

2

10

High-throughput

0.558

High

252722

RDH14
Retinol dehydrogenase 14

2

5

High-throughput

0.558

High

252727

NFIP2
NEDD4 family-interacting protein 2

2

1

High-throughput

0.558

High

252653

DRD2
D(2) dopamine receptor

1

11

High-throughput

0.541

High

252661

MC4R
Melanocortin receptor 4

1

16

High-throughput

0.541

High

252674

EWS
RNA-binding protein EWS

1

2

High-throughput

0.541

High

252700

RL3R2
Relaxin-3 receptor 2

1

20

High-throughput

0.541

High

252724

LT4R2
Leukotriene B4 receptor 2

1

20

High-throughput

0.541

High

165491

SCAM3
Secretory carrier-associated membrane protein 3

1

6

High-throughput

0.536

High

168785

PLD2
Phospholipase D2

1

1

High-throughput

0.536

High

252652

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

High-throughput

0.536

High

252655

LEG3
Galectin-3

1

10

High-throughput

0.536

High

252656

S1PR1
Sphingosine 1-phosphate receptor 1

1

20

High-throughput

0.536

High

252657

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

16

High-throughput

0.536

High

252663

OPRX
Nociceptin receptor

1

10

High-throughput

0.536

High

252665

RAB13
Ras-related protein Rab-13

1

1

High-throughput

0.536

High

252666

GPM6A
Neuronal membrane glycoprotein M6-a

1

1

High-throughput

0.536

High

252667

CCR6
C-C chemokine receptor type 6

1

12

High-throughput

0.536

High

252668

VAMP7
Vesicle-associated membrane protein 7

1

2

High-throughput

0.536

High

252672

PAR2
Proteinase-activated receptor 2

1

20

High-throughput

0.536

High

252678

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

20

High-throughput

0.536

High

252683

ZDH20
Palmitoyltransferase ZDHHC20

1

9

High-throughput

0.536

High

252698

DGLB
Diacylglycerol lipase-beta

1

3

High-throughput

0.536

High

252704

CLC2B
C-type lectin domain family 2 member B

1

11

High-throughput

0.536

High

252707

PAQR1
Adiponectin receptor protein 1

1

1

High-throughput

0.536

High

252715

CCG6
Voltage-dependent calcium channel gamma-6 subunit

1

1

High-throughput

0.536

High

252728

GPC5D
G-protein coupled receptor family C group 5 member D

1

3

High-throughput

0.536

High

252687

RHDF2
Inactive rhomboid protein 2

1

0

High-throughput

0.513

High

252732

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.513

High

252735

O10H1
Olfactory receptor 10H1

1

0

High-throughput

0.513

High

252736

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.513

High

170574

CLGN
Calmegin

1

5

High-throughput

0.489

High

252660

AOFB
Amine oxidase [flavin-containing] B

1

1

High-throughput

0.489

High

252677

TRI32
E3 ubiquitin-protein ligase TRIM32

1

1

High-throughput

0.489

High

252682

KCP3
Keratinocyte-associated protein 3

1

1

High-throughput

0.489

High

252688

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.489

High

252705

TM9S4
Transmembrane 9 superfamily member 4

1

5

High-throughput

0.489

High

252709

BSCL2
Seipin

1

3

High-throughput

0.489

High

252712

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

2

High-throughput

0.489

High

252719

TMX1
Thioredoxin-related transmembrane protein 1

1

5

High-throughput

0.489

High

252720

AT133
Polyamine-transporting ATPase 13A3

1

17

High-throughput

0.489

High

252723

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

1

High-throughput

0.489

High

252729

TM181
Transmembrane protein 181

1

5

High-throughput

0.489

High

217587

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

252654

INGR1
Interferon gamma receptor 1

1

1

High-throughput

0.479

High

252662

ACV1B
Activin receptor type-1B

1

5

High-throughput

0.479

High

252689

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

252691

LRP10
Low-density lipoprotein receptor-related protein 10

1

6

High-throughput

0.479

High

252726

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

14

High-throughput

0.479

High

252737

KC1G3
Casein kinase I isoform gamma-3

1

2

High-throughput

0.479

High

252716

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.460

High

252708

CHP3
Calcineurin B homologous protein 3

1

2

High-throughput

0.457

High

252664

SATT
Neutral amino acid transporter A

1

2

High-throughput

0.445

High

252703

CTL1
Choline transporter-like protein 1

1

5

High-throughput

0.445

High

252649

P53
Cellular tumor antigen p53

1

2

High-throughput

0.437

High

252690

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

252734

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.437

High

252680

CEGT
Ceramide glucosyltransferase

3

0

High-throughput

0.347

High

252711

CDC6
Cell division control protein 6 homolog

3

0

High-throughput

0.347

High

252702

TM171
Transmembrane protein 171

2

0

High-throughput

0.328

High

252721

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

252679

SNX17
Sorting nexin-17

2

0

High-throughput

0.318

High

252676

SEC20
Vesicle transport protein SEC20

1

0

High-throughput

0.279

Low

252696

FBCD1
Fibrinogen C domain-containing protein 1

1

0

High-throughput

0.279

Low

252701

SFT2A
Vesicle transport protein SFT2A

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025